First look: Notre Dame at USC odds and lines

Looking at Saturday’s Notre Dame at USC college football odds, lines and trends. Here’s what you need to know.

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The No. 5 Notre Dame Fighting Irish (10-1) and the USC Trojans (6-5) meet Saturday at the Los Angeles Memorial Coliseum. Kickoff is scheduled for 3:30 p.m. ET (CBS). Below, we look at Notre Dame vs. USC odds from BetMGM Sportsbook’s college football odds before making our expert college football picks and predictions later in the week.

The Fighting Irish pounded previously unbeaten Army at Yankee Stadium Saturday, 49-14, easily covering as a 14-point favorite as the Over (44.5) cashed in a battle of ranked teams.

Notre Dame has won 9 straight games, while covering 7 in a row, since that stunning 16-14 loss to Northern Illinois back on Sept. 7. The Over has cashed in 3 of the past 4 games for Notre Dame, while going 5-2 in the past 7 games.

USC held off rival UCLA Saturday at the Rose Bowl, securing bowl eligibility as a result. USC has covered consecutive games for the first time since Sept. 1-7 when it had wins over LSU and Utah State to start the season.

The Under has cashed in 3 straight games for the Trojans, and the 13 points allowed to UCLA were the fewest USC has given up since Sept. 7, a shutout win over Utah State.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Notre Dame at USC odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Monday at 9:33 a.m. ET.

  • Moneyline (ML): Notre Dame -250 (bet $250 to win $100) | USC +200 (bet $100 to win $200)
  • Against the spread: Notre Dame -7.5 (-110) | USC +7.5 (-110)
  • Over/Under (O/U): 51.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Notre Dame 10-1 | USC 6-5
  • ATS: Notre Dame 9-2 | USC 7-4
  • O/U: Notre Dame 6-5 | USC 5-6

Notre Dame vs. USC head-to-head

Notre Dame leads the all-time series 49-37-5, including a 48-20 win last season in South Bend.

USC won the most recent game at home, 38-27, but that is the only victory for the Trojans in the past 6 tries since Oct. 21, 2017.

USC does hold a slight 5-4 ATS edge in the past 9 meetings since Nov. 29, 2014, while the Over has cashed in each of the past 2 meetings and 6 of the previous 9 outings.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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