Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Cleveland Guardians (83-62) and Chicago White Sox (33-113) wrap up a 3-game series Wednesday. First pitch from Guaranteed Rate Field is set for 2:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Guardians vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Guardians lead 7-5

The Guardians limited the White Sox to just 5 hits in a 5-0 victory on Tuesday night, and Cleveland has outscored Chicago 10-2 in the 1st 2 games of the series. The struggling White Sox had actually split the 1st 10 games of the season series entering this 3-game set.

Since the Kansas City Royals pulled into a tie atop the AL Central on Aug. 27, Cleveland has won 8 of the past 12 outings, while the Under is on a 8-0-2 run in the previous 10 contests.

The White Sox have dropped 4 of the past 5 outings, while going 3-20 in the previous 23 contests dating back to Aug. 17. The Under has cashed in 4 of the past 5 outings, too.

Guardians at White Sox projected starters

LHP Matthew Boyd vs. RHP Davis Martin

Boyd (2-1, 2.20 ERA) makes his 6th start. He has a 0.77 WHIP, 1.6 BB/9 and 8.2 K/9 in 28 2/3 IP.

  • Last start: Win, 6 IP, 1 ER, 3 H (1 solo HR), 0 BB, 6 K in a 3-1 road victory vs. Los Angeles Dodgers Friday
  • 2024 road splits: 1-0, 3.18 ERA, 11 1/3 IP, 4 ER, 3 HR, 0.97 WHIP, .171 opponents’ batting average (OBA), 4 BB, 8 K in 2 starts
  • Career vs. White Sox: 4-9, 5.12 ERA, 89 2/3 IP, 51 ER, 16 HR, 1.48 WHIP, 10.1 K/9 in 18 starts

Martin (0-3, 3.29 ERA) makes his 8th start and 9th appearance. He has a 1.28 WHIP, 3.5 BB/9 and 8.2 K/9 in 38 1/3 IP.

  • Last start: No-decision, 6 IP, 1 ER, 3 H, 1 BB, 3 K in 3-1 road loss vs. Boston Red Sox Friday
  • 2024 home splits: 0-1, 3.44 ERA, 18 1/3 IP, 7 ER, 3 HR, 1.47 WHIP, .257 OBA, 8 BB, 18 K in 4 appearances (3 starts)
  • Career vs. Guardians: Loss, 6 IP, 4 ER, 8 H, 2 BB, 3 K in 4-1 road setback at Progressive Field July 12, 2022, in only career start

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Guardians at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 11:47 p.m. ET.

  • Moneyline (ML): Guardians -225 (bet $225 to win $100) | White Sox +188 (bet $100 to win $188)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (-130) | White Sox +1.5 (+108)
  • Over/Under (O/U): 8 (O: -112 | U: -108)

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Guardians at White Sox picks and predictions

Prediction

Guardians 3, White Sox 2

Moneyline

The Guardians (-225) will set you back more than 2 times your potential return. That’s way too much risk against one of the worst, if not the worst teams in history, the White Sox (+188).

Cleveland hasn’t crushed Chicago pitching, averaging a respectable, but not overwhelming, 5.0 runs per game in this series. But, the Guardians pitching has held the toothless White Sox offense to just 3 total runs, or 1.5 runs per game.

PASS.

Run line/Against the spread

The WHITE SOX +1.5 (+108) are worth a look in the series finale, if you’d like a little insurance, but just cannot play the bumbling team straight up.

While Martin has a dismal 0-3 record, the ERA of 3.29 is very respectable, and the right-handed probably deserves better. Chicago has managed just 14 runs of offense support in Martin’s 7 starts, or 2.0 runs per game (RPG), and it isn’t likely to get much better on Wednesday afternoon.

Over/Under

UNDER 8 (-108) is the best play on the board in this battle under the sun on the south side.

Again, Chicago is averaging 2.0 RPG of offensive support in Martin’s 7 starts, while it ranks last in the majors with just 3.1 RPG this season, with only 115 homers and a .618 OPS, both of which are also last in the majors.

For Cleveland, total bettors have loved it lately, with the total going low at a 8-0-2 run in the past 10 games since Aug. 31.

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