New Orleans Saints at San Francisco 49ers odds, picks and predictions

Analyzing Sunday’s New Orleans Saints at San Francisco 49ers odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (0-1) welcome the New Orleans Saints (1-0) to Levi’s Stadium Sunday. Kickoff is set for 8 p.m. ET (FOX). Below, we analyze FanDuel Sportsbook’s lines around the Saints vs. 49ers odds, and make our expert NFL picks and predictions.

The 49ers, among the best teams in the NFL over the last few seasons, lost its preseason opener to the Tennessee Titans 17-13. Backup QB Joshua Dobbs passed for 146 yards and an INT. First-round draft pick WR Ricky Pearsall  didn’t have a catch in the 1st preseason game.

New Orleans won its preseason opener 16-14 over the Arizona Cardinals. Starting QB Derek Carr went 2-of-6 for 12 yards.

Saints at 49ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:38 a.m. ET.

  • Moneyline (ML): Saints +100 (bet $100 to win $100) | 49ers -120 (bet $120 to win $100)
  • Against the spread (ATS): Saints  +1.5 (-110) | 49ers -1.5 (-110)
  • Over/Under (O/U): 38.5 (O: -115 | U: -105)

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Saints at 49ers picks and predictions

Prediction

49ers 20, Saints 17

Moneyline

BET 49ERS (-120).

The 49ers being in front of their own fans should help. The better case here is the fact the starters may get a few series which should result in points, and the backups are experienced quarterbacks in Dobbs and QB Brandon Allen.

The Saints backups are more of a wild card in QB Spencer Rattler. New Orleans may have beaten Arizona, but they were 5-of-15 on 3rd down and committed 9 penalties. Those shortcomings will be tough to overcome against San Francisco.

Given those preseason issues for New Orleans, take 49ERS (-120).

Against the spread

PASS.

Given how similar the spread and moneyline are, avoid the added risk and take the home team’s moneyline play. While not a bad option for bettors, avoid this play and look above.

Over/Under

BET UNDER 38.5 (-105).

Neither team’s 2nd unit looked overly impressive in their 1st outing. The Saints gained just 286 total yards and were not great in sustaining drives.

The 49ers scored just 13 points, and their QBs combined to go 21-of-33. San Francisco was just 4-for-11 on 3rd down as well and 0-for-2 on 4th down.

Both teams held their opponent to 17 or fewer. Given those trends, take UNDER 38.5 (-105).

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