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The New York Mets (21-27) and Cleveland Guardians (32-17) wrap up a 3-game interleague series at Progressive Field Wednesday. First pitch is scheduled for 1:10 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Mets vs. Guardians odds and make our expert MLB picks and predictions for the best bets.
Season series: Guardians lead 2-0
The Guardians won the opener 3-1 on Monday as -119 favorites, and Cleveland held off New York 7-6 on Tuesday as -115 favorites. Cleveland has won 5 straight games, and 8 of the past 9 outings, as it continues to lead the AL Central over the Kansas City Royals by 1 1/2 games.
Cleveland is 17-6 at home, the fewest amount of losses at home in the majors, while posting a plus-62 run differential in 49 games, good for 5th in the majors in that category.
The Mets have suffered losses in 4 of the past 5 outings, while posting a 3-9 record across the previous 12 contests. New York has dropped 5 consecutive interleague games, too, while going just 3-8 in 11 games against AL opponents.
Mets at Guardians projected starters
LHP Jose Quintana vs. RHP Triston McKenzie
Quintana (1-4, 5.21 ERA) makes his 10th start. He has a 1.46 WHIP, 3.5 BB/9 and 6.2 K/9 in 46 2/3 IP.
- Last start: No-decision, 5 1/3 IP, 2 ER, 4 H, 0 BB, 4 K in a 6-5 road win in 11 innings vs. Philadelphia Phillies last Thursday
- 2024 road splits: 1-2, 7.13 ERA (24 IP, 19 ER), 2 HR, 31 H, 10 BB, 18 K in 5 starts
- 2024 daytime splits: 1-1, 3.00 ERA (18 IP, 6 ER), 1 HR, 14 H, 6 BB, 11 K in 3 starts
McKenzie (2-3, 3.23 ERA) makes his 10th start. He has a 1.31 WHIP, 5.3 BB/9 and 7.6 K/9 in 47 1/3 IP.
- Last start: No-decision, 6 2/3 IP, 1 ER, 2 H (1 solo HR), 4 BB, 5 K in 3-2 home win vs. Minnesota Twins last Friday
- 2024 home splits: 2-1, 2.97 ERA (30 1/3 IP, 10 ER), 4 HR, 21 H, 22 BB, 27 K in 6 starts
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Mets at Guardians odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:41 a.m. ET.
- Moneyline (ML): Mets +108 (bet $100 to win $108) | Guardians -126 (bet $126 to win $100)
- Run line (RL)/Against the spread (ATS): Mets +1.5 (-205) | Guardians -1.5 (+168)
- Over/Under (O/U): 9 (O: -110 | U: -110)
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Mets at Guardians picks and predictions
Prediction
Guardians 6, Mets 4
Moneyline
The GUARDIANS (-126) are a good play against the southpaw Quintana, as they look to complete the 3-game interleague series sweep against the Mets (+108).
Quintana has struggled on the road, while McKenzie has been quite comfortable on his home mound.
Roll with the home side, and feel confident in doing so.
Run line/Against the spread
Cleveland is playing good baseball lately, and it is worth playing against the shaky left-hander. If you like the Guardians, just bet them straight up.
PASS.
Over/Under
OVER 9 (-110) is the lean, but go with a half-unit play at most.
The Under is 7-3 in the past 10 games for the Guardians, splitting in the 1st 2 games of this series.
The total has gone low in 4 straight starts by McKenzie, too, while the Under is 4-2 in Quintana’s past 6 assignments.
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