The Chargers are 12.5-point underdogs to the Bills in Week 16 of the 2023 regular season. The over/under is 44 points, per BetMGM Sportsbook.
That means oddsmakers are taking bets on whether the two teams will combine to score more than or fewer than 44 points.
My score prediction for the game is a 30-13 win for the Bills, with a combined total of 43 points. So if I were putting money behind my prediction, I’d bet the under.
As for game picks, analysts are picking Buffalo to win.
| Expert | Pick |
| Nate Davis (USA Today) | Bills |
| Jarrett Bell (USA Today) | Bills |
| Mike Clay (ESPN) | Bills |
| Matt Bowen (ESPN) | Bills |
| Pete Prisco (CBS Sports) | Bills |
| Vinnie Iyer (Sporting News) | Bills |
| NFL.com Staff | Bills (5 to 0) |
| Bleacher Report | Bills |
Saturday’s game will begin at 5:00 p.m. PT and will be televised on Peacock.