Colts vs. Jaguars: Prediction, point spread, best bet in Week 6

Take a look at our betting preview for the Week 6 matchup.

The Indianapolis Colts (3-2) play the Jacksonville Jaguars (3-2) on Sunday, and if you’re looking to do some last-minute betting research, you’re in luck! We’ll give you the latest point spread, money line odds and over/under number, as well as the information you’ll need to make the smartest bet.

The game starts at 1:00 p.m. ET and can be seen on CBS.

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This will be the second meeting between the Colts and Jaguars this season after opening the 2023 campaign with a game at Lucas Oil Stadium. The Jaguars won that game 31-20. The Colts haven’t beaten the Jaguars on the road since the 2014 season, losing the last eight matchups. Indy will be visiting Duval County without Anthony Richardson, who is on the injured reserve list due to a shoulder injury in his throwing arm.

  • Point spread: Colts +4.5
  • Money line: +165 Colts / -200 Jaguars
  • Over-under: 44

Colts vs. Jaguars injury report:

Colts RT Braden Smith (foot/wrist/hip) was ruled out on the final injury report while TE Mo Alie-Cox (concussion) and C Ryan Kelly (ankle/foot) are listed as questionable.

The Jaguars will be without CB Christian Braswell (hamstring), WR Zay Jones (knee), OL Walker Little (knee) and DT DaVon Hamilton (back). LB Devin Lloyd (thumb) is listed as questionable.

Check out the latest injury report here.

Advice and prediction

Colts: Josh Downs OVER 45.5 receiving yards (-110)

The rookie has essentially taken over the No. 2 wide receiver role through the first month of the season. He ranks second on the team in targets (33), receptions (23) and receiving yards (255) despite running the third-most routes and playing the third-most snaps among Colts wide receivers. He’s also coming off a breakout performance of six receptions for 97 yards in Week 5. Meanwhile, the Jaguars have allowed the ninth-most receiving yards (927) to the position through five games. Even with Gardner Minshew under center, Downs should be heavily involved as a quick-winning slot option, and he has a good chance of surpassing this line.

Prediction: Jaguars 24, Colts 21

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Get more betting analysis and predictions at Sportsbook Wire.