San Jose State at USC odds, picks and predictions

Analyzing Saturday’s San Jose State at USC odds and lines, with college football expert picks, predictions and best bets.

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The San Jose State Spartans will face the USC Trojans on Saturday in the first week of the college football season. Kickoff from Los Angeles Memorial Coliseum is scheduled for 8 p.m. ET (PAC-12 Network). Below, we analyze BetMGM Sportsbook’s lines around the San Jose State vs. USC odds, and make our expert college football picks and predictions.

San Jose State finished last season with a 7-4 record, ultimately losing 41-27 to Eastern Michigan in the Idaho Potato Bowl. Its only notable opponent was a 24-16 loss to Auburn in the 2nd week of the season. The Spartans finished 3rd in the Mountain West – West Division with a 6-0 home record.

USC finished last season with an 11-2 record, dropping its final game of the season 47-24 against Utah knocking them out of playoff contention. The Trojans fell 46-45 in a shootout against Tulane in the Cotton Bowl. They were the Pac-12 champions and QB Caleb Williams took home the 2022 Heisman Trophy.

USC is No. 6 in the USA TODAY Sports AFCA Coaches Poll.

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San Jose State at USC odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 9:45 a.m. ET,

  • Moneyline (ML): San Jose State +1600 (bet $100 to win $1,600) | USC -10000 (bet $10,000 to win $100)
  • Against the spread (ATS): San Jose State +30.5 (-110) | USC -30.5 (-110)
  • Over/Under (O/U): 66.5 (O: -110 | U: -110)

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San Jose State at USC picks and predictions

Prediction

USC 52, San Jose State 17

Moneyline

PASS.

With USC returning the reigning Heisman and seeking vengeance for its tragic end to last season, expect them to make a statement in this game. However, there is no profit to be made at -10000 odds.

Against the spread

SPRINKLE USC -30.5 (-110).

The Trojans opened the season with a 66-14 victory against Rice last year but only beat one other team — Colorado — by more than 30 points. This should be a tune-up game for USC and head coach Lincoln Riley will have his team ready to play with many starters returning. Expect a throttling, but 30.5 points is still a high margin of victory which merits just a sprinkle.

Over/Under

LEAN OVER 66.5 (-110).

Eleven of the Trojans’ 14 games went for more than 66.5 points last season with the offense scoring 30 or more points in 12 games. Williams and company run an offense that is high-powered and capable of finding the end zone on each drive. Expect San Jose State to put up a few points of its own once this game becomes out of reach which will allow the Over to cash.

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