Chicago White Sox at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The Chicago White Sox (47-72) and Chicago Cubs (61-57) open up a 2-game set at Wrigley Field Tuesday. First pitch is at 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-0

The White Sox’s down year continues as they have dropped 4 of their last 5 games and are just 6-14 over the last 20 games. The Sox also haven’t enjoyed interleague play much at 11-21 and are 14 1/2 games out in the AL Central with little shot at the postseason.

The Cubs are buzzin’. They are 14-6 and 20-10 over the last 20 and 30 games, respectively. They sit just 3 1/2 games behind the Milwaukee Brewers in the NL Central. The Cubbies are 20-18 in interleague play this season.

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White Sox at Cubs projected starters

RHP Touki Toussaint vs. RHP Kyle Hendricks

Toussaint (1-5, 4.27 ERA) makes his 8th start and 12th appearance. He has a 1.40 WHIP, 6.2 BB/9 and 9.1 K/9 in 46 1/3 innings with the White Sox and the Cleveland Guardians.

  • Last start: Loss, 5 IP, 4 ER, 6 H, 5 BB, 9 K last Tuesday against New York Yankees
  • 2023 home/road splits: 0-3, 5.47 ERA, 1.60 WHIP, 8.5 K/9 in 4 starts and 2 relief appearances on the road vs. 1-2, 2.70 ERA, 1.15 WHIP, 9.9 K/9 in 3 starts and 2 relief appearances at home

Hendricks (4-6, 3.96 ERA) makes his 16th start. He has a 1.12 WHIP, 1.5 BB/9 and 5.9 K/9 in 86 1/3 innings.

  • Last start: No-decision, 5 IP, 2 ER, 5 H, 2 BB, 6 K Wednesday against New York Mets
  • Last 5 starts vs. White Sox: 1-3, 6.43 ERA, 1.43 WHIP, 20 K in 28 IP

White Sox at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:23 a.m. ET.

  • Moneyline (ML): White Sox +140 (bet $100 to win $140) | Cubs -165 (bet $165 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-140) | Cubs -1.5 (+115)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

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White Sox at Cubs picks and predictions

Prediction

Cubs 6, White Sox 3

Moneyline

The Cubs won the first 2 games of the season series 10-7 and 7-3 in late July at Guaranteed Rate Field. The Baby Bears have taken 2 of 3 games from the Toronto Blue Jays and Atlanta Braves over their last 3 series, so they have beaten some impressive teams, although they did drop 2 of 3 games to the New York Mets between those series.

The Cubs aren’t as heavy favorites as I would expect, and I would consider taking them at -165. I’m looking a little bigger, though. Head to the Win/Total section and take the CUBS AND OVER 5.5 (+105) for a plus-money payout.

Run line/Against the spread

The Cubs are 32-28 on the RL at home, but I’d want a little more than +115 to pick them on a multi-run win here. We’re already getting +105 on the Cubs and Over 5.5 so if this were to swell up to +130 or more I’d throw it down.

PASS.

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Over/Under

The White Sox are 4-6 O/U over the last 10 games, and the Cubs are 5-5. Both of the previous games went Over and the Over is 6-3-1 in the last 10 meetings in this series. Toussaint has allowed 4 ER or more in 4 of his last 5 starts, and Hendricks has allowed 9 ER in 9 innings over his last 2 starts.

I like the OVER 8.5 (-115).

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