Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Thursday’s Cleveland Guardians at Chicago White Sox odds and lines, with expert MLB picks, predictions and best bets.

The Cleveland Guardians (51-51) and the Chicago White Sox (41-62) open a 4-game series Thursday at Guaranteed Rate Field. First pitch is scheduled for 8:10 p.m. ET (ESPN+). Let’s analyze BetMGM Sportsbook’s lines around the Guardians vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: White Sox lead 4-2

The Guardians moved back to .500 by taking 2 of 3 games from the Kansas City Royals this week, including an 8-3 win Wednesday as the Over (10) cashed. The Over is on a 7-3 run across the last 10 games for the Guardians.

The White Sox were swept in a 2-game interleague set with the rival Chicago Cubs Tuesday and Wednesday, and they have now dropped 5 in a row. Pitching has been an issue, allowing 34 runs during the skid, or 6.8 runs per game (RPG). The Over is 4-1 during the 5-game span.

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Guardians at White Sox projected starters

RHP Tanner Bibee vs. RHP Dylan Cease

Bibee (6-2, 3.04 ERA) makes his 16th start. He has a 1.19 WHIP, 3.1 BB/9 and 9.2 K/9 in 83 innings.

  • Last start: Win, 7 IP, 0 ER, 2 H, 1 BB, 8 K in a 1-0 home win vs. the Philadelphia Phillies Saturday
  • 2023 road splits: 2-1, 4.38 ERA (37 IP, 18 ER – 6 HR), .274 opponent batting average (OBA) in 7 starts

Cease (4-3, 4.04 ERA) makes his 22nd start. He has a 1.31 WHIP, 3.7 BB/9 and 10.9 K/9 in 113 2/3 innings.

  • Last start: No-decision, 6 IP, 1 ER, 3 H, 2 BB, 9 K in a 3-2 road loss vs. the Minnesota Twins Saturday
  • 2023 home splits: 1-2, 4.04 ERA (55 2/3 IP, 25 ER – 7 HR), .242 OBA in 10 starts
  • 2023 vs. Cleveland: 1-1, 12 1/3 IP, 5 ER, 10 H (2 HR), 3 BB, 6 K in 2 starts

Guardians at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:45 a.m. ET.

  • Moneyline (ML): Guardians -105 (bet $105 to win $100) | White Sox -115 (bet $115 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-210) | White Sox -1.5 (+170)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

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Guardians at White Sox picks and predictions

Prediction

Guardians 4, White Sox 3

Moneyline

The GUARDIANS (-105) are worth a look in this series opener behind Bibee, who has posted a pair of quality starts in his last 2 outings.

In addition, the White Sox (-115) use a heavy right-handed lineup, and Chicago has the 4th-worst on-base percentage vs. RHP. In addition, Chicago is 0-6 in the past 6 tries against a right-handed starting pitcher, while going 1-10 in the previous 11 vs. RHP.

Run line/Against the spread

The Guardians +1.5 (-210) will cost you over 2 times your potential return if you cannot play Cleveland straight up and require a little insurance.

PASS.

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Over/Under

UNDER 8.5 (-115) is the lean in this series opener between divisional rivals.

The Under has cashed in 4 straight starts between these AL Central foes, including the last 2 outings by Cease against Cleveland.

The Under is 3-2 in the last 5 for the Guardians, while going 4-2 in the last 6 divisional games for the White Sox.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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