The San Diego Padres (23-27) begin a 3-game series against the New York Yankees (30-22) on Friday at Yankee Stadium. First pitch is scheduled for 7:05 p.m. ET (Apple TV+). Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Yankees odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting since the Yankees took 2 of 3 games from the Padres in 2019
The Padres secured an 8-6 victory over the Washington Nationals on Thursday. San Diego is just 4-6 in its last 10 contests despite that it has won 3 of its last 4 games.
The Yankees fell to the Baltimore Orioles 3-1 Thursday, handing them a 2nd consecutive loss. New York has still gone 7-3 in its last 10 games and is in 3rd place in the AL East, trailing the Tampa Bay Rays by 7 games.
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Padres at Yankees projected starters
RHP Joe Musgrove vs. RHP Randy Vasquez
Musgrove (1-2, 6.75 ERA) makes his 6th start. He has a 1.58 WHIP, 3.4 BB/9 and 9.4 K/9 through 24 IP.
- Has surrendered 3-plus runs in 4 of his first 5 outings
- Has given up at least 1 HR in 4 of his first 5 starts
Vasquez will make his major league debut. He has a 1-5 record with a 4.85 ERA, 1.57 WHIP, 4.9 BB/9 and 10.5 K/9 through 42 2/3 IP in 9 starts in Triple-A this season.
- Has allowed 3-plus ER in 5 of his 9 starts
- Has gone 5-plus innings in 5 consecutive starts after failing to hit that mark for his first 4 outings of the season
Padres at Yankees odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:41 a.m. ET.
- Moneyline (ML): Padres -115 (bet $115 to win $100) | Yankees -105 (bet $105 to win $100)
- Run line (RL)/Against the spread (ATS): Padres -1.5 (+135) | Yankees +1.5 (-160)
- Over/Under (O/U): 9 (O: -120 | U: +100)
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Padres at Yankees picks and predictions
Prediction
Yankees 6, Padres 5
Moneyline
Even with the Padres having the more experienced pitcher, the YANKEES (-105) are the pick in this matchup. New York is 10-1 in its last 11 interleague games against a right-handed pitcher.
Run line/Against the spread
YANKEES +1.5 (-160) is how I’d wager on the run line in this interleague showdown if you’d like to get a run of insurance and aren’t totally comfortable with the moneyline. However, I wouldn’t bet this line any steeper than -160.
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Over/Under
OVER 9 (-120) is an enticing wager with Musgrove sputtering to begin the season and Vasquez making his debut in the majors. The Yankees boast the 4th-best ISO (.206) against right-handed pitchers at home this season, so they should produce a decent number of runs on Musgrove.
New York has gone Over in 9 of its last 10 home games.
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