Tennessee advances to the Sweet 16 for the ninth time in program history and for the first time since 2019.
Olivier Nkamhoua scored 23 of his game-high 27 points in the second half. He also totaled five rebounds.
Santiago Vescovi recorded 14 points, five rebounds and five assists for the Vols.
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Jonas Aidoo scored eight points, all in the first half, and recorded five rebounds. Josiah-Jordan James finished with eight points and five rebounds for Tennessee.
Tyrese Proctor led the Blue Devils with 16 points, while Jeremy Roach and Kyle Filipkowski totaled 13 points each.