The New Orleans Saints (4-7) look to snap a 3-game road losing streak when they meet the San Francisco 49ers (6-4) Sunday at 4:25 p.m. (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Saints vs. 49ers odds, and make our expert NFL picks and predictions.
The Saints won last week with a 27-20 win over the punchless Rams to keep them with sniffing distance of 1st place in the eminently mediocre NFC South – where 4-7 still makes you a contender.
The 49ers started the season 3-4, but have hit their stride once running back Christian McCaffrey has been incorporated into the offense. Their physical style on both sides of the ball is starting to click on all cylinders, highlighted by a 38-10 bludgeoning of division-rival Arizona Monday night in Mexico City.
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Saints at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:45 a.m. ET.
- Moneyline (ML): Saints +350 (bet $100 to win $350) | 49ers -425 (bet $425 to win $100)
- Against the spread (ATS): Saints +8.5 (-109) | 49ers -8.5 (-111)
- Over/Under (O/U): 43 (O: -112 | U: -108)
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Saints vs. 49ers key injuries
Saints
- DE Marcus Davenport (calf) questionable
- RB Mark Ingram (knee) questionable
- DE Cameron Jordan (eye) questionable
- CB Marshon Lattimore (abdomen) questionable
- OL Andrus Peat (triceps) questionable
- LB Pete Werner (ankle) out
49ers
- DL Arik Armstead (foot, ankle) doubtful
- WR Deebo Samuel (hamstring) questionable
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Saints vs. 49ers picks and predictions
Prediction
49ers 31, Saints 17
Moneyline
PASS.
The Niners should be to take care of their business and giving away a 4.5 rate of return doesn’t make sense.
Against the spread
BET 49ERS -8.5 (-111).
The Saints had 9 key players that either missed or were limited in practice due to injuries this week. Nobody is injury-free at this point in the season, but that is an excessive number for a team going on the road to face one of the hotter teams in the league.
The 49ers are built to lay a ton of points, and the Saints’ last 2 losses have been by 14 and 10 points. When San Francisco wins, they almost always win big – their 6 wins this season have come by 20, 15, 22, 17, 6 and 28 points.
If you can’t match the 49ers physicality, they beat you into submission. This looks like a scenario likely to play out again for the banged-up Saints.
Over/Under
OVER 43 (-112) is the way to go.
The 49ers have scored 31 or more points in 2 of their last 3 games, and the Saints have scored 24 or more points in 6 of the last 8 games.
The wild card for me is the margin of victory the 49ers have piled up when things are going well. When they get a lead, they don’t go into a shell on either side of the ball. If the Niners score 31, that doesn’t require the Saints to do that much – even in garbage time late – to surpass this number.
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