The Los Angeles Rams (2-1) and San Francisco 49ers (1-2) will meet Monday night for the final game of Week 4. It’s a pivotal early-season divisional matchup in the NFC West. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the Rams vs. 49ers odds, and make our expert NFL picks and predictions.
The Rams are coming off a win over the Arizona Cardinals in Week 3, beating their division rivals 20-12. It was their 2nd straight win after an opening blowout loss to the Buffalo Bills. The offense is still trying to find its groove, but the defense held Arizona out of the end zone.
The 49ers will look to make it 7 wins in their last 8 games against the Rams. They had a 6-game winning streak over Los Angeles before losing in the divisional round in January, proving to have the Rams’ number in these annual matchups. San Francisco comes in with Jimmy Garoppolo at QB after losing Trey Lance for the year to an ankle injury.
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
Rams at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 2:26 p.m. ET.
- Money line (ML): Rams +105 (bet $100 to win $105) | 49ers -125 (bet $125 to win $100)
- Against the spread (ATS): Rams +1.5 (-107) | 49ers -1.5 (-115)
- Over/Under (O/U): 42.5 (O: -115 | U: -107)
Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!
Rams at 49ers key injuries
Rams
- C Brian Allen (knee) out
- CB David Long (groin) out
- WR Van Jefferson (knee) out
49ers
- LT Trent Williams (ankle) out
Play our free daily Pick’em Challenge and win! Play now!
Rams at 49ers picks and predictions
Prediction
Rams 21, 49ers 17
Money line
As previously mentioned, the 49ers have owned the Rams since 2018. They’ve gone 6-1 since then, but this is a game Los Angeles should be able to win – despite being on the road at Levi’s Stadium where it hasn’t won since 2018.
After seeing the 49ers struggle so badly against the Denver Broncos in Week 3, and watching the Rams shut down the Cardinals, I’m taking the RAMS (+105) to win outright.
Against the spread
It’s no surprise that the 49ers are favored at home against a team they’ve beaten 6 of the last 7 times, but the Rams feel like the better team coming into Week 4. And with how close many of these meetings have been over the last few years – 4 of the last 6 have been decided by 3 points or fewer – taking the points is the wiser move.
Bet the RAMS +1.5 (-107) to cover.
Over/Under
Neither of these offenses has looked very good this season. The Rams are 15th in points per game and the 49ers are 28th, so they have yet to find a rhythm on that side of the ball. Both teams boast impressive defenses, too, especially up front.
The total has gone Under in 4 of the last 5 meetings, and I think that’ll continue this week. Bet the UNDER 42.5 (-107).
Want action on this NFL game or any other matchups? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!
If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.
Follow @camdasilva on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]