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The Seattle Seahawks (1-0) visit the San Francisco 49ers (0-1) Sunday at Levi’s Stadium. Kickoff is at 4:05 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Seahawks vs. 49ers, and make our expert NFL picks and predictions.
After week 1 there are more questions surrounding these teams than answers. The 49ers came into a rainy Chicago and lost 19-10 to a Bears team that only managed 204 total yards. QB Trey Lance went 13-of-28 with a 50.3 passer rating. Backup QB Jimmy Garoppolo is looking like a better option each day.
The Seahawks pulled off an upset in what looked like a one-sided revenge game against the Denver Broncos. The Seahawks allowed 6.8 yards per play and put up just 5.2 themselves but somehow won. QB Geno Smith showed everyone why he beat out QB Drew Lock for the starting job, going 23-of-28 with 2 TDs and 0 INT.
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Seahawks at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:17 p.m. ET.
- Money line (ML): Seahawks +350 (bet $100 to win $350) | 49ers -450 (bet $450 to win $100)
- Against the spread (ATS): Seahawks +9.5 (-112) | 49ers -9.5 (-108)
- Over/Under (O/U): 40.5 (O: -117 | U: -103)
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Seahawks at 49ers key injuries
Seahawks
- S Jamal Adams (knee) out
- CB Artie Burns (groin) questionable
- CB Justin Coleman (calf) questionable
49ers
- LB Dre Greenlaw (elbow) questionable
- TE George Kittle (groin) questionable
- RB Elijah Mitchell (knee) out – injured reserve
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Seahawks at 49ers picks and predictions
Prediction
49ers 13, Seahawks 9
Money line
There are reasons to like the 49ers, their defense allowed the 3rd fewest yards in 2021 and they start 2022 in the same fashion. Running back Jeff Wilson Jr. can fill in the role left by RB Elijah Mitchell‘s week 1 injury and they are prime for a comeback.
The Seahawks benefited from Denver’s 2 endzone fumbles and some atrocious coaching decisions to pull off a win last week. They can’t expect such luck each week. Smith is also poised for regression after a strong start.
However, the lines are a bit too juicy to risk on the 49ers after their week 1 debacle. It’s best to AVOID.
Against the spread
The Seahawks are 5-2 ATS in their last 7 games as underdogs. This line is huge and likely based on preseason expectations instead of how these teams played in their openers.
BET SEAHAWKS +9.5 (-112).
Over/Under
The Under is 5-1 in Seahawks’ last 6 games as road underdogs — and it’s not just Seattle that points to a low-scoring game. The 49ers have gone Under 4 straight times following an outright loss.
LEAN UNDER 40.5 (-103).
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