Kansas City Chiefs at Arizona Cardinals odds, picks and predictions

The Kansas City Chiefs kick off their NFL season on the road against the Arizona Cardinals Sunday. Kickoff is 4:25 p.m. ET (CBS) at State Farm Stadium. Below, we analyze Tipico Sportsbook‘s lines around the Chiefs vs. Cardinals odds, and make our expert NFL picks and predictions.

The Chiefs bring a slightly new-look offense to 2022 after trading away speedy WR Tyreek Hill to the Miami Dolphins. They still have TE Travis Kelce, but have added receivers Marquez Valdes-Scantling and JuJu Smith-Schuster. They also lost 2 starting defensive backs in free agency.

The Cardinals inked QB Kyler Murray to a huge contract extension this offseason and added WR Marquise Brown to an already potent group of pass catchers. But they enter Week 1 with questions on defense due to a number of injuries.

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Chiefs at Cardinals odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:01 a.m. ET.

Money line (ML): Chiefs -270 (bet $270 to win $100) | Cardinals +220 (bet $100 to win $220)
Against the spread (ATS): Chiefs -6.5 (-108) | Cardinals +6.5 (-112)
Over/Under (O/U): 53.5 (O: -112 | U: -108)

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Chiefs at Cardinals key injuries

Chiefs

None

Cardinals

TE Zach Ertz (calf) questionable
WR Rondale Moore (hamstring) out
CB Byron Murphy (illness) questionable
OL Justin Pugh (neck) questionable
DE J.J. Watt (calf) questionable

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Chiefs at Cardinals picks and predictions

Prediction

Chiefs 27, Cardinals 24

Money line

At the beginning of the week, I liked the Cardinals for the upset. They have continuity on offense and defense and face a Chiefs team having to adjust to the absence of Hill and half their starting secondary from a year ago.

However, with injuries on offense and uncertainty at cornerback for the game, there is far less confidence in the Cardinals being able to keep up.

The price to bet the Chiefs isn’t worth it. PASS.

Against the spread

The Chiefs still have questions on defense. They have a rookie starting at cornerback and don’t look like they will be any better against the run. The Cardinals have a full stable of running backs to control the tempo, even without 2 of their receivers, with DeAndre Hopkins suspended 6 games and the speedy Moore out with a hamstring injury.

They have speed in Brown and length with WR A.J. Green.

The question is whether they can limit the Chiefs offense. It is expected to be more methodical and less flashy in 2022.

I anticipate the Cardinals will still keep this game close.

Take the points and go with CARDINALS +6.5 (-112).

Over/Under

Expecting a healthy group of pass catchers on both teams and questions at cornerback for both Arizona and Kansas City, I initially expected a shootout. They would blow past that 53.5-point projected total and go into the 60s.

Now I believe things will be more methodical. Both teams will move the ball, but it will happen in longer, controlled drives.

Take UNDER 53.5 (-108).

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