The St. Louis Cardinals (70-52) and Chicago Cubs (53-69) continue their 5-game series at Wrigley Field with an 8:05 p.m. ET game on Wednesday. Let’s analyze Tipico Sportsbook‘s lines around the Cardinals vs. Cubs odds with MLB picks and predictions.
Season series: St. Louis leads 8-5
The Cardinals had an 8-game win streak snapped with a 2-0 loss in the opening tilt of a Tuesday doubleheader at Wrigley. The Cards bounced back with a 13-3 triumph in the nightcap. St. Louis has allowed just 6 runs through the first 3 games of this series.
The Cubs are 10 games under-.500 at home (27-37), but they’ve performed well at Wrigley in recent weeks. And pitching has led the way. Chicago owns a 3.15 ERA and a 10-5 mark in its last 15 games in front of the ivy.
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Cardinals at Cubs projected starters
RHP Miles Mikolas vs. RHP Luke Farrell
Mikolas (10-9, 3.32 ERA) has a 1.02 WHIP, 1.6 BB/9 and 6.8 K/9 through 157 1/3 IP in 25 starts.
- Filed a clunker at Coors Field Aug. 9, but has responded with 2 strong efforts since, allowing a combined 3 ER in the last 16 IP
- Operates with tilted home/road splits (4.45 road ERA since 2020 vs. 2.76 ERA at home)
Farrell is a 6-year Major League veteran making his 1st appearance this season.
- Has pitched in 63 games, making 5 starts, in his career
- Has a 5-5 record alongside a 4.93 ERA, 1.46 WHIP, 4.8 BB/9 and 9.6 K/9 in 87 2/3 career IP
- Registered a 5.03 and 1.46 WHIP in 59 IP thisyear at Triple-A Iowa
Cardinals at Cubs odds and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:09 a.m. ET.
- Money line: Cardinals -220 (bet $100 to win $220) | Cubs +175 (bet $175 to win $100)
- Run line (RL)/Against the spread (ATS): Cardinals -1.5 (-130) | Cubs +1.5 (+105)
- Over/Under (O/U): 8.5 (O: -112 | U: -108)
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Cardinals at Cubs picks and predictions
Prediction
Cubs 5, Cardinals 4
Money line
The Cards were a solid play over the first few weeks of August, but the scales now tip St. Louis a little bit into fade territory.
Mikolas is catching a Cubs attack on its best side (against right-handers) and playing well in its home yard.
Chicago is worth a straight-up play at +190. For any tag lower, WALK ON BY.
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Run line/Against the spread
Chicago has played in 41 one-run games; the MLB average is 34.
BACK THE CUBS +1.5 (+105).
Over/Under
PASS. Mikolas, Chicago bullpen, and batting-both sides — expectation versus production all the way around — are factors that crisscross. So, there’s no leverage to be found here.
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