Pittsburgh Pirates at St. Louis Cardinals odds, picks and predictions

Analyzing Wednesday’s Baltimore Orioles at New York Yankees odds and lines, with MLB expert picks and predictions.

The Pittsburgh Pirates (24-37) and St. Louis Cardinals (37-27) wrap up a 4-game series at Busch Stadium Wednesday at 7:45 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Pirates vs. Cardinals odds with MLB picks and predictions.

Season series: St. Louis leads 8-1

The Pirates were swept in a Tuesday doubleheader at Busch and have lost 6 in a row to the Redbirds. The Pirates tote a 9-game losing streak into this series finale. They have slashed a mere .190/.236/.309 (.545 OPS) during the stretch.

St. Louis pitching has led the way in the Cardinals going 5-1 over their last 6 games. Over that span, the Redbirds have registered a tidy 2.83 ERA.

Pirates at Cardinals projected starters

RHP Roansy Contreras vs. RHP Jack Flaherty

The rookie Contreras (1-1, 2.57 ERA) has clocked a 1.18 WHIP, 2.9 BB/9 and 10.6 K/9 through 28 IP in 7 games (4 starts).

  • Owns a 2.21 ERA over his last 20 1/3 IP – all 4 of his starts since May 24
  • Appeared in just 1 game last season, tossing 3 scoreless innings in his MLB debut during a home start vs. the Chicago Cubs Sept. 29

Flaherty is coming off the 60-day IL (shoulder) to make his 2022 debut. He went 9-2 with 3.22 ERA in 78 1/3 IP last season. He has a 3.34 career ERA across 5 MLB seasons.

  • Has held current Pittsburgh batters to a whiff-heavy .457 OPS
  • Notched a 2.61 ERA at Busch Stadium over 2020-21
  • Coming off 2 rehab efforts at Triple-A, and threw only 58 pitches in his most recent outing.

Pirates at Cardinals odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:02 p.m. ET.

  • Money line: Pirates +145 (bet $100 to win $145) | Cardinals -180 (bet $180 to win $100)
  • Run line (RL): Pirates +1.5 (-140) | Cardinals -1.5 (+115)
  • Over/Under (O/U): 8.5 (O: -112 | U: -108)

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Pirates at Cardinals picks and predictions

Prediction

Pirates 5, Cardinals 4

Money line

Contreras has been sharp and that’s been alongside a .357 batting average on balls in play. The Cards are a right-leaning lineup that does not do much damage against that side.

With Flaherty being a return-from-injury question mark and the back end of the St. Louis pen being on a pretty substantial fatigue watch, TAKE PITTSBURGH (+145).

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Run line/Against the spread

Same calculus as above, although both teams play few 1-run affairs. STEER CLEAR, but Pittsburgh +1.5 is worth a look at -140.

Over/Under

Mixed signals: PASS.

Pittsburgh is the 3rd-best Under team in the majors, posting a 23-32-6 O/U record. The Houston Astros are 1st at 19-43, just ahead of the Detroit Tigers’ 21-38-2 O/U mark. The Pirates are 12-16-3 O/U on the road.

St. Louis is 32-29-3 O/U, including an MLB 3rd-best 19-12-2 O/U mark at home. The Atlanta Braves’ 20-12-2 home O/U and the Cincinnati Reds’ 18-11 O/U at home rank 1st and 2nd, respectively.

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