The Los Angeles Rams (7-2) are on the road to visit the San Francisco 49ers (3-5) for Monday Night Football in Week 10. Kickoff from Levi’s Stadium will be at 8:15 p.m. ET. Below, we look at the Rams vs. 49ers odds and lines, and make our best NFL picks, predictions and bets.
The Rams are coming off their second loss of the season as they fell to the Tennessee Titans at home in lopsided fashion last Sunday night. The Rams had won four in a row coming into that game, all by at least nine points, but the Titans gave the Rams offense a lot of trouble and held them to only 16 points.
The 49ers have had a really disappointing season up to this point, dropping five of their last six games after starting the year 2-0. They were crushed 31-17 by the Arizona Cardinals in Week 9 despite the Cards being without both QB Kyler Murray and WR DeAndre Hopkins. QB Jimmy Garoppolo remains the starter but the 49ers are only 17th in scoring this season.
Rams at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 8:35 a.m. ET.
- Money line: Rams -190 (bet $190 to win $100) | 49ers +155 (bet $100 to win $155)
- Against the spread (ATS): Rams -3.5 (-108) | 49ers +3.5 (-112)
- Over/Under (O/U): 50.5 (O: -108 | U: -112)
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Rams at 49ers key injuries
Rams
- WR Robert Woods (knee) out
- C Brian Allen (elbow) questionable
- OLB Von Miller (ankle) questionable
- CB Darious Williams (ankle) questionable
- WR Ben Skowronek (thigh) questionable
49ers
- DT Maurice Hurst (calf) out
- DB Jimmie Ward (quad) questionable
- CB Josh Norman (rib) questionable
- S Tavon Wilson (foot) out
- RB JaMycal Hasty (ankle) out
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Rams at 49ers odds, lines, predictions and picks
Prediction
Rams 31, 49ers 21
Money line
The 49ers are trending in the wrong direction, and fast. Their only wins have come against the Detroit Lions, Philadelphia Eagles and Chicago Bears, while also losing last week to the Murray-less Cardinals. The Rams looked out of sorts against the Titans but don’t expect another performance like that from the offensive line tonight.
So long as the Rams can contain WR Deebo Samuel and keep DE Nick Bosa off of QB Matthew Stafford, they’ll win this game.
Bet the RAMS (-190) to win outright.
Against the spread
The 49ers are a paltry 2-6 against the spread this season and have only covered once in their last six games. The Rams have lost their last four games to the 49ers but Robert Saleh is no longer in San Francisco and he was a thorn in Sean McVay’s side, so I expect a better offensive performance tonight.
The Rams will bounce back from last week’s loss to the Titans and get off to a strong start against the 49ers. Bet the RAMS -3.5 (-108) to cover.
Over/Under
The Over has been a solid pick for both of these teams this season. The total has gone Over five times for each team and with the Rams offense playing well all year, I think it’s a good bet again on Monday night.
Seeing as the Over has hit in each of the 49ers’ last four games and in five of the Rams’ nine contests this year, I like the OVER 50.5 (-108).
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