The Los Angeles Rams (7-2) travel to meet the San Francisco 49ers (3-5) for Monday Night Football in Week 10 at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 8:15 p.m. ET. Below, we look at the Rams vs. 49ers odds and lines; check back for our NFL picks and predictions.
The Rams suffered a 28-16 loss at home Sunday night against the Tennessee Titans. Los Angeles has failed to cover its past three games overall.
The 49ers looked to be catching a break in Week 9 with the Arizona Cardinals missing QB Kyler Murray, WR DeAndre Hopkins and DE J.J. Watt. San Francisco still fell 31-17 at home, and it’s now 1-5 SU/ATS across the past six games overall.
Also see: All Week 10 odds and lines
Rams at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 7:15 a.m. ET.
- Money line: Rams -205 (bet $205 to win $100) | 49ers +165 (bet $100 to win $165)
- Against the spread (ATS): Rams -3.5, -115 (bet $115 to win $100) | 49ers +3.5, -105 (bet $105 to win $100)
- Over/Under (O/U): 48.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)
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2021 betting stats:
- ML: L.A. Rams 7-2 | San Francisco 3-5
- ATS: L.A. Rams 4-5 | San Francisco 2-6
- O/U: L.A. Rams 5-3-1 | San Francisco 5-3
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Rams at 49ers head-to-head
The NFC West Division rivals meet twice each season. San Francisco won its first-ever visit to SoFi Stadium in Week 12 last season, winning 23-20 as five-point underdogs as the Under cashed. The 49ers also won the meeting at Levi’s Stadium, topping the Rams 24-16 in Week 6 as 2.5-point ‘dogs as the Under connected. San Francisco is 4-0 SU/3-1 ATS in the past four meetings.
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