The Carolina Panthers (4-5) hit the road to face the Arizona Cardinals (8-1) Sunday in Week 10. Kickoff is at 4:05 p.m. ET at State Farm Stadium. Below, we look at the Panthers at Cardinals odds and lines; check back for our NFL picks and predictions.
The Panthers have struggled, losing five of their last six games after starting the season 3-0. QB Sam Darnold threw three interceptions in a 24-6 home loss to the New England Patriots in Week 9. RB Christian McCaffrey returned to the lineup after a stint on injured reserve and had 52 yards on 14 rushing attempts.
The Cardinals were shorthanded Sunday, playing without QB Kyler Murray, WR DeAndre Hopkins and WR A.J. Green, but still improved to 8-1 on the season and 5-0 on the road with a 31-17 victory over the San Francisco 49ers. Backup QB Colt McCoy passed for 249 yards and a touchdown, RB James Conner had 173 total yards from scrimmage with 3 touchdowns and the defense had 5 sacks and 3 takeaways.
Also see: All Week 10 odds and lines
Panthers at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 12:48 p.m. ET.
- Money line: Panthers +370 (bet $100 to win $370) | Cardinals -520 (bet $520 to win $100)
- Against the spread (ATS): Panthers +9.5, +100 (bet $100 to win $100) | Cardinals -9.5, -120 (bet $120 to win $100)
- Over/Under (O/U): 45.5, O: -105 (bet $105 to win $100) | U: -115 (bet $115 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Panthers 4-5 | Cardinals 8-1
- ATS: Panthers 4-5 | Cardinals 7-2
- O/U: Panthers 2-7 | Cardinals 4-5
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Panthers at Cardinals head-to-head
The two teams have met 15 times in the regular season and three times in the playoffs. Overall, the Panthers lead the all-time series 13-5 and have won the last five times they have played.
The Cardinals last beat the Panthers in 2013.
This will be the third straight year the two teams play. In 2019, Carolina QB Kyle Allen threw 4 touchdown passes in a 38-20 win in Arizona. In 2020, the Panthers won 31-21 at home behind 2 touchdown passes from QB Teddy Bridgewater.
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