Arizona Diamondbacks at Pittsburgh Pirates odds, picks and prediction

Analyzing Wednesday’s Arizona Diamondbacks at Pittsburgh Pirates odds and lines, with MLB picks and predictions.

The Arizona Diamondbacks (42-85) and Pittsburgh Pirates (46-80) meet Wednesday at PNC Park. First pitch is scheduled for 7:05 p.m. ET. Let’s analyze the lines around the Diamondbacks vs. Pirates odds with MLB picks and predictions.

LHP Tyler Gilbert is the projected starting pitcher for the Diamondbacks. He is 1-1 with a 2.04 ERA, 0.96 WHIP, 6.1 K/9 and 3.1 BB/9 through 17 2/3 IP over five games (two starts).

  • Back for start No. 3 after a no-hitter and a shaky follow-up outing in which he allowed 4 runs on 9 hits and 1 walk over 5 innings in a no-decision against the Colorado Rockies Friday.

RHP Bryse Wilson is the projected starter for the Pirates. He is 2-5 with a 4.82 ERA, 1.44 WHIP, 5.6 K/9 /and 2.1 BB/9 through 46 2/3 IP over 10 starts.

  • Reinstated from the 10-day IL (arm fatigue) for this start. Last pitched Aug. 14, so he wasn’t on the shelf for long.
  • Has been hurt by a .323 batting average on balls in play.

Diamondbacks at Pirates odds, lines, picks and prediction

MLB odds courtesy of Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 5:15 p.m. ET.

  • Money line: Diamondbacks -115 (bet $115 to win $100) | Pirates -105 (bet $105 to win $100)
  • Against the spread/ATS: Diamondbacks -1.5 (+140) | Pirates +1.5 (-180)
  • Over/Under: 8.5 (O: -135 | U: +110)

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Prediction

Pirates 6, Diamondbacks 5

Money line (ML)

Neither one of these clubs is going to be featured on the year-end 2021 MLB season summary video but there is some room to separate these two on a wager. The Pirates took the first two games of this series and look to be worth a partial-unit play Wednesday.

The Diamondbacks often struggle against right-handed pitchers and on the road. Gilbert likely gets overrated in this slot.

TAKE PITTSBURGH (-105).

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Run line/Against the spread (ATS)

AVOID the added juice on the spread. Plus, Pittsburgh tends to play relatively few games decided by a single run.

Over/Under (O/U)

The Steel City weather report calls for warm, humid conditions, with a hitter’s breeze out to right-center. Both starters figure to yield quite a few fly balls, so they figure to be more susceptible to those kinds of conditions.

With some fade lean on Gilbert and some growth signals in the batting analytics for both clubs there is a slight lean on the OVER 8.5 (-135).

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