Green Bay Packers at Buffalo Bills odds and lines: Bills look to stay on a roll

Looking at the NFL odds and lines for Saturday’s Green Bay Packers at Buffalo Bills preseason Week 3 matchup.

The Green Bay Packers (0-2) visit the Buffalo Bills (2-0) in a Week 3 preseason battle Saturday at 1 p.m. ET at Highmark Stadium. Below, we look at the Packers at Bills odds and lines; check back for our NFL picks and predictions.

Green Bay is coming off a Saturday home loss to the New York Jets. The Jets defeated the Packers 23-14 and Green Bay has scored just 21 points on 520 yards over two preseason games.

Buffalo defeated the Chicago Bears 41-15 Saturday. The Bills scored the first 28 points in the one-sided affair at Soldier Field. Solid defense held Chicago passers to a combined 20-for-36, and the Bears went a combined 1-for-15 on third and fourth downs.

The 2020 Bills went 8-1 over their final 10 regular and postseason games. The 2021 regular season schedule finds Buffalo at home three times in its first four games.

Packers at Bills: Odds, spread and lines

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 3 p.m. ET.

  • Money line: Packers +280 (bet $100 to win $280) | Bills -370 (bet $370 to win $100)
  • Against the spread/ATS: Packers +6.5, +100 (bet $100 to win $100) | Bills -6.5, -125 (bet $125 to win $100)
  • Total: 34.5, Over -115 (bet $115 to win $100) | Under -105 (bet $105 to win $100)

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2021 preseason betting stats:

  • ATS: Packers 0-2 | Bills 2-0
  • O/U: Packers 1-1 | Bills 1-1

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The Packers, at +280 odds, have an implied 26.32% chance of winning, or 14/5 fractional odds.

The Bills (-370) have an implied 78.72% chance of beating the Packers, or 10/37 fractional odds.

Green Bay would have to win outright or lose by 6 or fewer for the +6.5 (+100) ticket to cash. Buffalo would have to win by 7 or more for the -6.5 (-125) ticket to cash.

There would need to be at least 35 points scored for an OVER 34.5 (-115) ticket to cash, while a combined point total of 34 or fewer points is a win for the Under.

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