The Buffalo Bills (7-2) seek to win their fourth straight game and travel to take on the Arizona Cardinals (5-3) in Week 10. Kickoff is at 4:05 p.m. ET at State Farm Stadium. Below, we preview the Bills-Cardinals betting odds and lines and make our NFL picks and predictions.
Bills at Cardinals: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 10:30 a.m. ET.
- Money line: Bills +115 (bet $100 to win $115) | Cardinals -134 (bet $134 to win $100)
- Against the spread/ATS: Bills +2.5 (-110) | Cardinals -2.5 (-110)
- Over/Under: 56.5 (O: -110 | U: -110)
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Bills at Cardinals: Game notes
- Cardinals QB Kyler Murray threw for 283 yards and 3 touchdowns in a 34-31 loss to the Miami Dolphins in Week 9. He ran for 106 yards and a score.
- Bills QB Josh Allen had 415 passing yards and 3 touchdown passes in a 44-34 victory over the Seattle Seahawks in Week 9.
- The Cardinals have the No. 1 offense in the league, averaging 422.0 yards per game and are sixth in the league in scoring at 29.3 points per game.
- The Cardinals have the best point differential in the NFC at plus-54, while the Bills are plus-9.
- Arizona has the seventh-best third-down defense in the league, allowing opponents to convert 37.6% of their attempts. The Bills are third in the league in third-down offense, converting 50.5% of the time.
Bills at Cardinals: Key injuries
Bills
- S Micah Hyde (ankle) questionable
- CB Tre’Davious White (ankle) questionable
- G Cody Ford (ankle) questionable
Cardinals
- RB Kenyan Drake (ankle) questionable
- DL Jordan Phillips (hamstring) questionable
- CB Dre Kirkpatrick (thigh) questionable
- S Budda Baker (groin) questionable
Bills at Cardinals: Odds, betting lines, predictions and picks
Prediction
Cardinals 37, Bills 33
Money line (?)
This is a tough game to gauge. Both teams can put up points. Both teams move the ball well; however, Arizona’s defense has been a little better this season. Both units are expected to be at full strength. Buffalo has had equal success at home and on the road this season, losing one game each; Arizona is only 2-2 at home.
Picking a difference, which quarterback should a bettor trust more — Murray or Allen? Murray gets the nod, as he is less likely to turn the ball over. Take the CARDINALS (-134).
Against the spread (?)
Arizona has covered the spread in its wins and failed to do so in its three losses. Buffalo is 4-5 this season against the spread. They are 1-1 ATS as underdogs. Since we like the Cardinals to win straight up and they have not picked up a win without a cover, take the CARDINALS -2.5 (-110).
Over/Under (?)
The Cardinals did not have a game go Over the total in their first six games. Their last two have, though. Buffalo is 6-2-1 O/U and both teams have offenses that are humming. This is a lock. Take OVER 56.5 (-110).
Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Also see:
- What to know from the Cardinals’ Week 10 depth chart (Cards Wire)
- QB Josh Allen wins FedEx Air Player of the Week (Bills Wire)
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