DE Calais Campbell

Every year Campbell is one of the best defensive players in the league with none of the adoration or awards. The 33-year-old defensive end is having another solid season with 38 total tackles, 5.5 sacks, 9.5 tackles for a loss, one forced fumble and one blocked kick.

The laundry list of stats is something the Colts offensive line has to account for. The matchup of the day might be Anthony Castonzo vs Campbell on the outside. Given whoever is under center time to throw will be key in this game and Campbell loves to disrupt opposing offenses.

The Colts will also have to be weary of Campbell moving inside to line-up against right guard Mark Glowinski, which is a matchup the Jaguars can exploit.