WR Brandon Aiyuk among 6 49ers out of 1st practice leading up to regular-season opener

Kyle Shanahan gave an injury update after Wednesday’s practice. The good news is he thinks everyone out Wednesday will be back for Week 1.

49ers head coach Kyle Shanahan spoke with reporters after Wednesday’s practice and gave an update on the absences from the first practice leading up to the regular season.

There don’t appear to be any long-term issues ahead. Shanahan said the expectation is for all the players to return by Week 1, although he didn’t provide any guarantees.

Quarterback Trey Lance went through some drills, but didn’t take any snaps or make any real throws while he nurses a small chip on the index finger on his throwing hand. He wasn’t included in Shanahan’s update.

Here’s who was out Wednesday: