WATCH: Seattle Seahawks at Indianapolis Colts, Week 1, Key Facts, Stats

See betting lines, statistical trends and relevant facts for the 2021 NFL season opener between the Seattle Seahawks and Indianapolis Colts.

The Indianapolis Colts host the Seattle Seahawks Sunday to open their respective seasons. The Colts lost their last seven season openers, but the Seahawks lost each of their last three road openers as favorites.

Seattle is the favorite, but Indianapolis won eight of its last nine home games against NFC opponents, including three of four as a home underdog. Go to Tipico Sportsbook for the most updated odds.

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