4. San Francisco vs. 13. Seattle
How San Francisco can win: The 49ers have the greatest quarterback of all time throwing to Hall of Famer wide receiver Lynn Swann, potential Hall of Famer receiver Davante Adams and tight end Brent Jones. They’ll supplement that with a dominant rushing attack featuring O.J. Simpson and Marshawn Lynch. Seattle won’t have the horses to get stops on defense, even with Ndamukong Suh in the middle, and its offensive attack just doesn’t have enough firepower to take advantage of a shaky front seven and keep up with Brady and the 49ers offense. — Kyle Madson, Niners Wire
How Seattle can win: The Seahawks like to play from behind with a chip on their shoulders, and they might start this round doing just that. The defense will have to channel the Legion of Boom’s intensity to stifle the likes of QB Tom Brady and RBs O.J. Simpson and Marshawn Lynch. Budda Baker, Lawyer Milloy and Ndamukong Suh will need to bring their A-games, but the Niners might be too formidable an opponent to overcome. — Liz Mathews, Seahawks Wire
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Other matchups:
Hou vs Den / LAC vs Buf / Jax vs KC / Cin vs Ten / Pit vs Bal / Cle vs Ind / NYJ vs LV / Mia vs NE // Dal vs Min / Was vs NYG / Atl vs TB / Car vs Ari / LAR vs GB / Phi vs Det / NO vs Chi