Defense (42)
| Pos. | First | Second | Third |
| LDE | Alex Okafor | Breeland Speaks | Demone Harris, Taco Charlton |
| LDT | Chris Jones | Khalen Saunders | Tershawn Wharton |
| RDT | Derrick Nnadi | Mike Pennel | Devaroe Lawrence |
| RDE | Frank Clark | Tanoh Kpassagnon | Mike Danna, Tim Ward |
| LB | Anthony Hitchens | Willie Gay Jr. | Ben Niemann, Darius Harris |
| LB | Damien Wilson | Dorian O’Daniel | Emmanuel Smith, Omari Cobb |
| LCB | Charvarius Ward | Antonio Hamilton | Hakeem Bailey |
| RCB | Bashaud Breeland | L’Jarius Sneed | Chris Lammons |
| SCB | Rashad Fenton | Alex Brown | Lavert Hill |
| FS | Daniel Sorensen | Tedric Thompson | |
| SS | Tyrann Mathieu | Armani Watts | Rodney Clemons |
Observations:
- The Chiefs signed free agent DB Tedric Thompson after realizing that Juan Thornhill wouldn’t be ready to start training camp and would be placed on the PUP list. I’m still listing Sorensen ahead of Thompson at free safety, but I anticipate Thompson getting the majority of snaps in single-high looks.
- Rookie CB BoPete Keyes is starting out on the non-football injury list. I didn’t anticipate him as more than a third-string corner in Kansas City to start anyways.
- DT Braxton Hoyett, LB Bryan Wright, CB Javaris Davis, DB Andrew Soroh and DB Jalen Julius were all waived.