UFC London predictions: Can Sean Brady change the guard vs. ex-champ Leon Edwards?

Check out our staff members’ picks and analysis for UFC Fight Night 255 in London.

The UFC is back in London this week with a two former champions in fights at the top of the card.

UFC Fight Night 255 (ESPN+) takes place Saturday at The O2 in London.

Get pick results from our 11 editors, writers, radio hosts and videographers, as well as additional analysis, below.

Morgan Charriere vs. Nathaniel Wood

Nathaniel Wood

Records: Charriere (20-10-1 MMA, 2-1 UFC), Wood (20-6 MMA, 8-3 UFC)
Past five: Charriere 4-1, Wood 4-1
Division: Featherweight
Rankings: None
Odds (as of 03.21.25): Charriere -140, Wood +120
Junkie pick results: Wood 6, Charriere 5

Chris Duncan vs. Jordan Vucenic

Jordan Vucenic

Records: Duncan (12-2 MMA, 3-1 UFC), Vucenic (13-3 MMA, 0-1 UFC)
Past five: Duncan 4-1, Vucenic 4-1
Division: Lightweight
Rankings: None
Odds (as of 03.21.25): Duncan +350, Vucenic -455
Junkie pick results: Vucenic 7, Duncan 4

Molly McCann vs. Alexia Thainara

Alexia Thainara

Records: McCann (14-7 MMA, 7-6 UFC), Thainara (11-1 MMA, 0-0 UFC)
Past five: McCann 2-3, Thainara 5-0
Division: Women’s strawweight
Rankings: None
Odds (as of 03.21.25): McCann +180, Thainara -220
Junkie pick results: Thainara 7, McCann 4

Kevin Holland vs. Gunnar Nelson

Gunnar Nelson

Records: Holland (26-13 MMA, 13-10 UFC), Nelson (19-5-1 MMA, 10-5 UFC)
Past five: Holland 1-4, Nelson 3-2
Division: Welterweight
Rankings: None
Odds (as of 03.21.25): Holland +100, Nelson -120
Junkie pick results: Nelson 8, Holland 3

Jan Blachowicz vs. Carlos Ulberg

Jan Blachowicz

Records: Blachowicz (29-10-1 MMA, 12-7-1 UFC), Ulberg (12-1 MMA, 7-1 UFC)
Past five: Blachowicz 2-2-1, Ulberg 5-0
Division: Light heavyweight
Rankings: Blachowicz No. 6, Ulberg No. 9
Odds (as of 03.21.25): Blachowicz +235, Ulberg -290
Junkie pick results: Blachowicz 6, Ulberg 5

Leon Edwards vs. Sean Brady

Leon Edwards vs. Sean Brady

Records: Edwards (22-4 MMA, 14-3 UFC), Brady (17-1 MMA, 7-1 UFC)
Past five: Edwards 4-1, Brady 4-1
Division: Welterweight
Rankings: Edwards No. 2, Brady No. 7
Odds (as of 03.21.25): Edwards +130, Brady -155
Junkie pick results: Brady 6, Edwards 5

Preliminary card picks

Although they don’t count toward the standings, MMA Junkie staff members still pick the fights on the prelims. Here are the results:

Shauna Bannon
  • Jai Herbert vs. Chris Padilla: Padilla 6, Herbert 5
  • Felipe dos Santos vs. Lone’er Kavanagh: Kavanagh 9, dos Santos 2
  • Mick Parkin vs. Marcin Tybura: Tybura 6, Parkin 5
  • Christian Leroy Duncan vs. Andrey Pulyaev: Duncan 10, Pulyaev 1
  • Shauna Bannon vs. Puja Tomar: Bannon 10, Tomar 1
  • Nathan Fletcher vs. Caolan Loughran: Loughran 6, Fletcher 5
  • Kaue Fernandes vs. Guram Kutateladze: Kutateladze 10, Fernandes 1

Check out all the main card picks below.

(Click here to open a PDF of the staff picks grid in a separate window.)

Edwards
vs.
Brady
Blachowicz
vs.
Ulberg
Holland
vs.
Nelson
McCann
vs.
Thainara
Duncan
vs.
Vucenic
Charriere
vs.
Wood
MMA Junkie readers’
consensus picks
27-19
edwards2025
Edwards
(56%)
ulberg2025
Ulberg
(58%)
holland2025
Holland
(52%)
thainara2025
Thainara
(60%)
vucenic2025
Vucenic
(59%)
wood2025
Wood
(56%)
Farah Hannoun
@Farah_Hannoun
33-13
trophy copy 2024 Champion
edwards2025
Edwards
blachowicz2025
Blachowicz
nelson2025
Nelson
mccann2025
McCann
duncan2025
Duncan
charriere2025
Charriere
Nolan King
@mma_kings
29-17
trophy copy 2023 Champion
edwards2025
Edwards
blachowicz2025
Blachowicz
holland2025
Holland
thainara2025
Thainara
vucenic2025
Vucenic
charriere2025
Charriere
Brian Garcia
@thegoze
28-18
trophy copy 2017 Champion
brady2025
Brady
blachowicz2025
Blachowicz
holland2025
Holland
mccann2025
McCann
vucenic2025
Vucenic
wood2025
Wood
Matt Erickson
@MattE
27-19
brady2025
Brady
ulberg2025
Ulberg
nelson2025
Nelson
thainara2025
Thainara
vucenic2025
Vucenic
wood2025
Wood
Ken Hathaway
@1khathaway
27-19
trophy copy 2017, 2022, 2024 Champion
brady2025
Brady
ulberg2025
Ulberg
nelson2025
Nelson
thainara2025
Thainara
duncan2025
Duncan
charriere2025
Charriere
Abbey Subhan
@kammakaze
26-20
edwards2025
Edwards
blachowicz2025
Blachowicz
nelson2025
Nelson
mccann2025
McCann
vucenic2025
Vucenic
wood2025
Wood
Mike Bohn
@MikeBohn
26-20
trophy copy 2014 Champion
brady2025
Brady
blachowicz2025
Blachowicz
nelson2025
Nelson
thainara2025
Thainara
duncan2025
Duncan
wood2025
Wood
Simon Samano
@SJSamano
25-21
edwards2025
Edwards
ulberg2025
Ulberg
nelson2025
Nelson
thainara2025
Thainara
vucenic2025
Vucenic
charriere2025
Charriere
George Garcia
@MMAjunkieGeorge
25-21
edwards2025
Edwards
ulberg2025
Ulberg
holland2025
Holland
mccann2025
McCann
duncan2025
Duncan
wood2025
Wood
Danny Segura
@dannyseguratv
24-22
brady2025
Brady
blachowicz2025
Blachowicz
nelson2025
Nelson
thainara2025
Thainara
vucenic2025
Vucenic
wood2025
Wood
Matthew Wells
@MrMWells
22-24
brady2025
Brady
ulberg2025
Ulberg
nelson2025
Nelson
thainara2025
Thainara
vucenic2025
Vucenic
charriere2025
Charriere

For more on the card, visit MMA Junkie’s event hub for UFC Fight Night 255.