3. Holmes battles back
In 2011, J.B. Holmes had a quarter-dollar-sized piece of his skull removed during brain surgery to relieve pressure caused by a structural defect called Chiari malformation. He returned to the course in 2012 and went on to win the 2014 Wells Fargo Championship, 2015 Shell Houston Open, 2019 Genesis Open and played for the victorious U.S. team in the 2016 Ryder Cup.