Tennessee Titans at Indianapolis Colts odds, picks and predictions

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The Indianapolis Colts (2-2) welcome the Tennessee Titans (2-2) to Lucas Oil Stadium Sunday. Kickoff is set for 1 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Titans vs. Colts odds, and make our expert NFL picks and predictions.

The Colts lost to the Los Angeles Rams 29-23 at home in Week 4, failing to cover as a 1-point home underdog. Indy is 2-2 against the spread (ATS) this season and has been an underdog in all 4 games. It is 0-2 ATS and 0-2 straight up at home. Star RB Jonathan Taylor could return and is listed as questionable. The Colts are led by rookie QB Anthony Richardson, who has 7 total touchdowns through 3 games.

The Titans are coming off a 27-3 home win over the Cincinnati Bengals, covering as a 2.5-point underdog. They have also been an underdog in each game and are 3-1 ATS. Tennessee is 0-2 straight up on the road yet 1-1 ATS. RB Derrick Henry is the main contributor, running for 285 yards through 4 games. QB Ryan Tannehill has struggled this season with 4 interceptions and just 788 passing yards.

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Titans at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 11:25 a.m. ET.

Moneyline (ML): Titans -145 (bet $145 to win $100) | Colts +120 (bet $100 to win $120)
Against the spread (ATS): Titans -2.5 (-110) | Colts +2.5 (-110)
Over/Under (O/U): 43 (O: -110 | U: -110)

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Titans at Colts key injuries

Titans

WR Treylon Burks (knee) out
LB Luke Gifford (hamstring) out
DT Teair Tart (toe) out
DT Jeffery Simmons (ankle) unspecified

Colts

LB Shaquille Leonard (groin) out
DE Kwity Paye (concussion) out
OT Bernhard Raimann (concussion) out
RB Jonathan Taylor (ankle) questionable

Titans at Colts picks and predictions

Prediction

Colts 24, Titans 17

Moneyline

SPRINKLE COLTS (+120).

The Titans are 0-2 on the road, losing 16-15 to the New Orleans Saints in Week 1 and 27-3 to the Cleveland Browns in Week 3.

Indianapolis may have its star back, which should bode well for its offense, one that has topped 20 points in every game. The Titans have given up 27 or more points in 2 of 4 games this season.

Expect the Colts to be able to run on Tennessee and score enough to win this game. Back COLTS (+120).

Against the spread

BET COLTS +2.5 (-110).

The Titans have yet to be a favorite this season, and they will go on the road and be a favorite as well. With Tannehill having a turnover-prone first month, Tennessee shouldn’t be favored here.

Indianapolis was 2-1 ATS as a home underdog last season, and it has scored 76 points over its last 3 games. The Titans have gone 15 or under in 2 of 3 games.

The consistency of the Colts offense should keep this game close enough for them to cover. Back COLTS +2.5 (-110).

Over/Under

LEAN UNDER 43 (-110).

The Titans are 1-3 O/U and are 0-2 O/U on the road this season. The Colts are 3-1 O/U but have not topped 23 points when playing at home this season.

Both teams rank in the top half of the league in run play percentage with Tennessee 10th and Indy 15th. Expect them to take the air out of the ball and run often. That clock should keep ticking and fewer points scored.

Take UNDER 43 (-110).

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