Tampa Bay Buccaneers at Indianapolis Colts odds, picks and prediction

Analyzing Sunday’s Tampa Bay Buccaneers at Indianapolis Colts odds and lines, with expert NFL picks, predictions and best bets.

The Tampa Bay Buccaneers (7-3) are the road against the red-hot Indianapolis Colts (6-5) Sunday in Week 12. Kickoff from Lucas Oil Stadium will be at 1 p.m. ET. Below, we look at the Buccaneers vs. Colts odds and lines, and make our best NFL picks, predictions and bets.

The Buccaneers snapped their two-game losing skid with a 30-10 win over the New York Giants on Monday Night Football. They lead the league in scoring and are second in total yards per game, and they are ninth in points allowed per game and eighth total yards allowed per game.

QB Tom Brady has put together an MVP-caliber season with a league-high 29 touchdown passes and 317.7 yards per game.

The Colts are in the midst of a three-game win streak, beating the New York Jets, Jacksonville Jaguars and Buffalo Bills. RB Jonathan Taylor leads the NFL with 1,122 rushing yards and 13 touchdowns as he helps carry a team that ranks fifth in scoring and 11th in total yards per game.

Buccaneers at Colts odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 9:22 a.m. ET.

  • Money line: Buccaneers -160 (bet $160 to win $100) | Colts +130 (bet $100 to win $130)
  • Against the spread (ATS): Buccaneers -3.5 (+102) | Colts +3.5 (-125)
  • Over/Under (O/U): 52.5 (O: -115 | U: -105)

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Buccaneers at Colts key injuries

Buccaneers

  • WR Antonio Brown (ankle) out
  • G Ali Marpet (abdomen) doubtful
  • LB Devin White (quadriceps) questionable
  • DL Vita Vea (knee) questionable

Colts

  • LB Darius Leonard (ankle) questionable
  • G Quenton Nelson (ankle) questionable

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Buccaneers at Colts odds, lines, predictions and picks

Prediction

Buccaneers 27, Colts 21

Money line

The Colts go as Taylor does. If he’s running the ball well, they’re going to have success. However, he and the Colts are facing the best run defense in the NFL this week. The Bucs have allowed just 784 yards on 206 carries, both the fewest in football.

The Bucs will win if they can shut down Taylor. Bet the BUCS (-160) to win.

Against the spread

The Colts have been great against the spread (ATS) this season, going 7-4. The Bucs have only gone 4-6 ATS and are 1-2 ATS in their last three games.

The Buccaneers are just 0-5-1 ATS against the Colts in their last six meetings and they’ve split 3-3 SU. I like the BUCS -3.5 (+102) to cover the spread Sunday, though.

Over/Under

The total has gone Over in five of the Bucs’ 10 games this season but is 7-4 for the Colts, including four of their last five games.

Indianapolis has impressively topped 30 points in five of its last six games. However, with the Bucs’ defense so stout against the run, I think the Colts could struggle. Bet the UNDER 52.5 (-105).

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