Takeaways from 49ers 24-20 loss to Cardinals

San Francisco 49ers quarterback Jimmy Garoppolo struggled, two RBs emerge, and other takeaways from their Week 1 loss to Arizona.

WR issues hard to overcome

Kyle Terada-USA TODAY Sports

Deebo Samuel is on Injured Reserve with a foot injury, and Brandon Aiyuk was ruled out before the game with a hamstring injury. That gave San Francisco just four healthy wide receivers. Dante Pettis, Kendrick Bourne, Trent Taylor and Richie James Jr. combined for just four catches for 41 yards on 11 targets. Samuel is out for the next two games at least, but it’s clear they at least need Aiyuk in the lineup if their receiving corps is going to be effective.