Chicago White Sox at Cleveland Guardians odds, picks and predictions

Analyzing Tuesday’s Chicago White Sox at Cleveland Guardians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (6-3) face the Cleveland Guardians (4-5) Tuesday in the opener of what is now a three-game set. First Pitch from Progressive Field in Cleveland is scheduled for 6:10 p.m. ET (ESPN+). Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.

Season series: White Sox won the 2021 series 10-9

These teams were expected to open a four-game set Monday, but a chilly rain/snow mix washed out the opener which has been rescheduled for July 12. The White Sox won five of the nine meetings in Cleveland last season.

The Guardians opened the season with wins in four of their first six games — all on the road — but were swept in a three-game interleague set against the San Francisco Giants over the weekend, so they’re still looking for the first home win of 2022.

White Sox at Guardians: Projected starters

LHP Dallas Keuchel vs. RHP Shane Bieber

Keuchel (1-0, 5.40 ERA) makes his second start. He allowed 3 ER on 6 H and 0 BB with 5 K across 5 IP in his first start versus the Seattle Mariners Wednesday.

  • Posted a 4-7 record and 5.75 ERA with a .310 opponent batting average across 81 1/3 IP in 16 road starts in 2021.
  • Managed a 0-1 record, 6.61 ERA and 4 home runs allowed in just 16 1/3 IP across three starts versus Cleveland last season.

Bieber (0-0, 2.70 ERA) allowed 3 ER on 2 H and 3 BB with 5 K in 5 1/3 IP at the Cincinnati Reds in his second start of the season last Tuesday. This will be his first home outing of 2022.

  • Went 2-2 with a 3.51 ERA with 53 strikeouts over 41 IP across seven starts at Progressive Field in 2021.
  • Managed a tremendous 3-0 record, 1.80 ERA and .169 OBA with 32 K and no HR allowed across 25 IP in four starts against the White Sox last season.

White Sox at Guardians odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:20 a.m. ET.

  • Money line (ML): White Sox +120 (bet $100 to win $120) | Guardians -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-180) | Guardians -1.5 (+145)
  • Over/Under (O/U): 7.5 (O: -115 | U: -107)

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White Sox at Guardians picks and predictions

Prediction

Guardians 4, White Sox 2

Money line

The GUARDIANS (-145) are worth playing as moderate favorites at home. The home side caught a break with the weather Monday, as they’ll now be able to use their ace for this series opener.

While Cleveland hasn’t really supported its Opening Day starter with a lot of offense, he’ll break through against a team he showed well against in 2021.

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Run line/Against the spread

GUARDIANS -1.5 (+145) are worth playing very lightly on the run line. Bieber had a tremendous hold on the White Sox last season, racking up three of his seven victories against the Pale Hose. The offense has struggled a bit lately after flying high in Kansas City and Cincinnati, so be careful.

Over/Under

The UNDER 7.5 (-107) might be the best play on the board here.

The Under is 5-1 in the past six games for the ChiSox against a right-handed starting pitcher, while going 7-2-1 in the past 10 as an underdog going back to last season. The Under is also 11-5-1 in the past 17 road games for Chicago.

While the Over is 5-2 in the past seven for Cleveland, the Under is 5-2 in the past seven at Progressive Field, including 2-1 this season. Cleveland’s offense scratched out just 4 total runs in the three-game sweep at the hands of San Francisco.

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Chicago White Sox at Cleveland Indians odds, picks and prediction

Analyzing Thursday’s Chicago White Sox at Cleveland Indians odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (86-67) continue their five-game series with the Cleveland Indians (75-77) Friday. First pitch from Progessive Field is scheduled for 7:10 p.m. ET. Let’s analyze the lines around the White Sox vs. Indians odds with MLB picks and predictions.

These teams split a seven-inning doubleheader Thursday with the White Sox winning the first 7-2 and the Indians taking the second game 5-3.

Season series: Tied 8-8.

RHP Dylan Cease is Chicago’s projected starter. Cease is 12-7 with a 4.09 ERA (156 1/3 IP, 71 ER), 1.26 WHIP, 3.8 BB/9 and 12.2 K/9 across 30 starts.

  • Last outing: Win, 8-0, with 5 IP, 0 ER, 4 H, 2 BB and 10 K Sept. 17 at the Texas Rangers.
  • Cease lost 6-5 on the road in his only start against Cleveland this season with 3 1/3 IP, 6 ER, 8 H, 1 BB and 2 K.
  • vs. Indians on the current roster (31 PA): 5.70 FIP with a .333 batting average (BA), .440 wOBA, .427 expected slugging percentage (xSLG), 32.3 K% and 88.4 mph exit velocity (EV).

RHP Shane Bieber makes his 15th start for the Indians. Bieber is 7-4 with a 3.28 ERA (90 2/3 IP, 33 ER), 1.25 WHIP, 3.3 BB/9 and 12.9 this year.

  • Last outing: Loss, 6-2, with 5 2/3 IP, 5 ER, 10 H, 2 BB and 8 K June 13 vs. the Seattle Mariners.
  • Bieber is 3-0 in three starts this season against Chicago with a 2.05 ERA (22 IP, 5 ER), 0.86 WHIP and 7.3 K/BB.
  • vs. White Sox on the current roster (164 PA): 3.05 FIP with a .250 BA, .303 wOBA, .387 xSLG, 32.9 K% and 90.1 mph EV.

White Sox at Indians odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 1:40 p.m. ET.

  • Money line: White Sox -120 (bet $120 to win $100) | Indians +100 (bet $100 to win $100)
  • Against the spread/ATS: White Sox -1.5 (+135) | Indians +1.5 (-170)
  • Over/Under: 7.5 (O: -130 | U: +105)

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Prediction

Indians 6, White Sox 3

Money line (ML)

GIMME the INDIANS (+100) for 1 unit because Bieber’s pitching peripherals and basic numbers against the White Sox are far better than Cease’s against Cleveland’s lineup.

Chicago is a bad road team and Cease’s pitching performance declines when he’s away from home. The White Sox are 37-40 overall on the road and Cease has a 5.02 road ERA (3.22 ERA at home) and a 1.37 road WHIP (1.16 WHIP at home).

Furthermore, Chicago is kind of snoozing down the stretch with not much to play for – the White Sox are 5-5 overall in their last 10 games – and these teams have played to a draw thus far.

Lastly, we have “reverse line movement” in the betting market as nearly 90% of the cash wagered has been on Chicago but the line is moving in Cleveland’s direction, according to Pregame.com. Whenever the sportsbook makes the more popular side cheaper it suggests they believe that side is mispriced.

If you’re giving me an even- or a plus-money payout with the reigning AL Cy Young at home against a team he’s dominated, how can I pass? BET the INDIANS (+100).

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Run line/Against the spread (ATS)

PASS because the Indians +1.5 (-170) is a terrible bet considering Cleveland is 15-18 ATS as a home underdog even though getting a run-and-a-half worth of insurance with Bieber on the mound would be awesome.

Over/Under (O/U)

TAKE OVER 7.5 (-130) for 1 unit because the presumed sharp side of the market is backing the Over while the public is betting the Under.

Close to 90% of the money is on the Over but roughly 70% of the bets placed are on the Under according to Pregame.com at the time of writing.

Typically, it’s profitable to follow the money in sports betting when it’s flowing in the opposite direction as the public.

Furthermore, there are several Over-friendly trends in this White Sox-Indians matchup including these teams being a combined 22-19 O/U record when these starters are on the mound.

Also, the Under is heavily juiced, which suggests the oddsmakers want more pro-Over bets. We don’t want to play into the House’s hands.

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Chicago White Sox at Cleveland Indians Game 1 odds, picks and prediction

Analyzing Thursday’s Chicago White Sox at Cleveland Indians Game 1 odds and lines, with MLB expert picks and predictions.

The Chicago White Sox (85-66) and Cleveland Indians (74-76) will play a doubleheader Thursday to open a five-game series that runs through the weekend. First pitch for Game 1 is set for 1:10 p.m. ET at Progressive Field. Let’s analyze the lines around the White Sox vs. Indians odds with MLB picks and predictions.

White Sox RHP Reynaldo Lopez (3-3, 3.00 ERA) makes his 18th appearance (8th start). He has a 0.94 WHIP, 2.3 BB/9 and 8.8 K/9 through 48 IP.

  • Has been pretty solid this season, though not quite as good as the ERA would suggest, as he has been helped by a .229 BABIP.
  • He is coming off his worst outing of the year where he served up 7 ER over 4 IP against the Angels. He has registered a 4.50 ERA and 8.0 K/9 through 28 IP across his seven starts.

Indians RHP Aaron Civale (11-4, 3.40 ERA) makes his 19th start. He has a 1.09 WHIP, 2.2 BB/9 and 7.2 K/9 through 111 1/3 IP.

  • Missed more than two months due to a sprained finger, and has made three starts since his return from the injured list. He’s had mixed results over that span that total 6 ER allowed over 13 2/3 IP with a 13/4 K/BB.
  • Has put up a 3.81 ERA and 7.3 K/9 across 54 1/3 IP through his nine home starts.

White Sox at Indians Game 1 odds, lines, picks and prediction

MLB odds provided by Tipico Sportsbook; access USA TODAY Sports for a full list. Odds last updated at 10:27 a.m. ET.

  • Money line: White Sox -135 (bet $135 to win $100) | Indians +110 (bet $100 to win $102)
  • Against the spread/ATS: White Sox -1.5 (+133) | Indians +1.5 (-165)
  • Over/Under: 6.5 (O: -135 | U: +110)

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Prediction

White Sox 5, Indians 3

Money line (ML)

Civale has been decent since his return, but his fastball velocity is down almost a full tick and he has a weak 7.3% swinging-strike rate. He has managed to deliver two pretty good starts and one bad one during that stretch, and he’ll face a tough test against a Chicago team that ranks seventh in runs scored and sixth in wRC+ against right-handed pitching league-wide.

Back the WHITE SOX (-135).

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Run line/Against the spread (ATS)

This looks like a pretty even matchup that could very well stay close throughout. There doesn’t appear to be much value on either side of this line, so the wise move is to simply PASS on the run line.

Over/Under (O/U)

Civale isn’t quite back to being his usual self yet, as the velocity and whiffs are down since he has come back from a lengthy IL stint. On the other side, not surprisingly, Lopez hasn’t been quite as good in a starting role as he is in relief.

As part of a doubleheader, keep in mind that this will be a seven-inning game. Neither pitcher is looking too dominant right now, so look for the offenses to muster enough runs to push the total OVER 6.5 (-135).

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Chicago White Sox at Cleveland Indians odds, picks and prediction

Analyzing Tuesday’s Chicago White Sox at Cleveland Indians odds and lines, with MLB picks and predictions.

The Chicago White Sox (33-21) and Cleveland Indians (29-24) play the third game of a four-game set Tuesday. First pitch at Progressive Field is set for 6:10 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the White Sox vs. Indians odds with MLB picks and predictions.

2021 series: Tied 5-5

The AL Central rivals split a doubleheader Monday with the White Sox taking the opener 8-6 in eight innings and the Indians winning the nightcap 3-1.

RHP Dylan Cease is projected to start for Chicago Tuesday. He is 3-1 with a 2.98 ERA (51 1/3 IP, 17 ER), 1.27 WHIP, 11.6 K/9 and 4.6 BB/9 in 10 starts this season.

  • Last outing: Win, 6 IP, 1 ER, 4 H, 2 BB, 10 K in 5-1 home decision vs. Baltimore Orioles Thursday
  • Career vs. Indians: 1-1, 5.14 ERA (14 IP, 8 ER), 1.43 WHIP, 7 BB, 16 K in 3 starts
  • 2020 vs. Indians: 1-1, 4.91 ERA (7 1/3 IP, 4 ER), 9 H, 5 BB, 5 K in 2 starts

RHP Shane Bieber is the Indians’ projected starter. He is 5-3 with a 3.13 ERA (72 IP, 25 ER), 1.21 WHIP, 13.8 K/9 and 3.4 BB/9 in 11 starts.

  • Last outing: Win, 7 IP, 1 ER, 1 H, 4 BB, 12 K in 5-2 victory at Detroit Tigers Thursday
  • Career vs. White Sox: 4-2, 2.67 ERA (64 IP, 19 ER), 1.05 WHIP, 12.0 K/9 in 10 starts
  • 2021 vs. White Sox: 2-0, 1.80 ERA (15 IP, 3 ER), 10 H, 2 BB, 22 K in 2 starts

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA and WV. New customer offers, terms and conditions apply.

  • Bet just $1 on either team’s money line, WIN $100 (in free bets) if either team hits a home run during the game. Bet now!
  • RISK-FREE FIRST BET. Place your first bet, if it loses you’ll get up to $600 in free bets. Bet now!

White Sox at Indians odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 9:31 a.m. ET.

  • Money line: White Sox +130 (bet $100 to win $130) | Indians -155 (bet $155 to win $100)
  • Against the spread/ATS: White Sox +1.5 (-165) | Indians -1.5 (+130)
  • Over/Under: 7 (O: -120 | U: +100)

Prediction

White Sox 4, Indians 3

Money line (ML)

If you follow sports enough you know favorites don’t always win. Cleveland ace Bieber is one of the best pitchers in baseball, but the value is in the WHITE SOX (+130) here, making them my STRONGEST PLAY – 1½ times your usual wager.

Sure, Bieber is 2-0 vs. Chicago this year, but he was 1-2 with a 3.96 ERA (36 1/3 IP, 16 ER) the previous two seasons. So, it’s not like he’s invincible.

I’ll take my chances with WHITE SOX (+130), who are 12 games over .500 and outscoring opponents by an AL-best 80 runs.

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Run line/Against the spread (ATS)

PASS. While I like the White Sox to win, I’m not willing to play a run line with -165 juice. I’ll stick with the ML.

ATS records: White Sox 31-23 | Indians 29-24

Over/Under (O/U)

PASS. Under bettors have been cashing in on the White Sox – the Under is 13-5 in their last 18 games. However, the projected score hits the O/U 7 line on the nose.

O/U records: White Sox 23-31 | Indians 27-24-2

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Bet on this game now at BetMGM Sportsbook. For more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

JOHNNY’S RECORD W-L SP ROI
2021 MLB 55-51-2 18-18-1 +0.69
2020 MLB 80-59-1 39-21 +24.79
2021 (all sports) 158-137-3 67-60-1 +12.59
*SP: Strongest plays; ROI: Return on investment

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Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage. This information is for entertainment purposes only. We make no representations or warranties as to the accuracy, completeness, or reliability of any content.

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Chicago White Sox at Cleveland Indians odds, picks and prediction

Analyzing Tuesday’s Chicago White Sox at Cleveland Indians odds and lines, with MLB picks and predictions.

The Chicago White Sox (33-21) and Cleveland Indians (29-24) play the third game of a four-game set Tuesday. First pitch at Progressive Field is set for 6:10 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the White Sox vs. Indians odds with MLB picks and predictions.

2021 series: Tied 5-5

The AL Central rivals split a doubleheader Monday with the White Sox taking the opener 8-6 in eight innings and the Indians winning the nightcap 3-1.

RHP Dylan Cease is projected to start for Chicago Tuesday. He is 3-1 with a 2.98 ERA (51 1/3 IP, 17 ER), 1.27 WHIP, 11.6 K/9 and 4.6 BB/9 in 10 starts this season.

  • Last outing: Win, 6 IP, 1 ER, 4 H, 2 BB, 10 K in 5-1 home decision vs. Baltimore Orioles Thursday
  • Career vs. Indians: 1-1, 5.14 ERA (14 IP, 8 ER), 1.43 WHIP, 7 BB, 16 K in 3 starts
  • 2020 vs. Indians: 1-1, 4.91 ERA (7 1/3 IP, 4 ER), 9 H, 5 BB, 5 K in 2 starts

RHP Shane Bieber is the Indians’ projected starter. He is 5-3 with a 3.13 ERA (72 IP, 25 ER), 1.21 WHIP, 13.8 K/9 and 3.4 BB/9 in 11 starts.

  • Last outing: Win, 7 IP, 1 ER, 1 H, 4 BB, 12 K in 5-2 victory at Detroit Tigers Thursday
  • Career vs. White Sox: 4-2, 2.67 ERA (64 IP, 19 ER), 1.05 WHIP, 12.0 K/9 in 10 starts
  • 2021 vs. White Sox: 2-0, 1.80 ERA (15 IP, 3 ER), 10 H, 2 BB, 22 K in 2 starts

MLB betting offers/promotions

BetMGM Sportsbook offers available in CO, IA, IN, MI, NJ, PA, TN, VA and WV. New customer offers, terms and conditions apply.

  • Bet just $1 on either team’s money line, WIN $100 (in free bets) if either team hits a home run during the game. Bet now!
  • RISK-FREE FIRST BET. Place your first bet, if it loses you’ll get up to $600 in free bets. Bet now!

White Sox at Indians odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 9:31 a.m. ET.

  • Money line: White Sox +130 (bet $100 to win $130) | Indians -155 (bet $155 to win $100)
  • Against the spread/ATS: White Sox +1.5 (-165) | Indians -1.5 (+130)
  • Over/Under: 7 (O: -120 | U: +100)

Prediction

White Sox 4, Indians 3

Money line (ML)

If you follow sports enough you know favorites don’t always win. Cleveland ace Bieber is one of the best pitchers in baseball, but the value is in the WHITE SOX (+130) here, making them my STRONGEST PLAY – 1½ times your usual wager.

Sure, Bieber is 2-0 vs. Chicago this year, but he was 1-2 with a 3.96 ERA (36 1/3 IP, 16 ER) the previous two seasons. So, it’s not like he’s invincible.

I’ll take my chances with WHITE SOX (+130), who are 12 games over .500 and outscoring opponents by an AL-best 80 runs.

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Run line/Against the spread (ATS)

PASS. While I like the White Sox to win, I’m not willing to play a run line with -165 juice. I’ll stick with the ML.

ATS records: White Sox 31-23 | Indians 29-24

Over/Under (O/U)

PASS. Under bettors have been cashing in on the White Sox – the Under is 13-5 in their last 18 games. However, the projected score hits the O/U 7 line on the nose.

O/U records: White Sox 23-31 | Indians 27-24-2

PLAY: Free, daily sports pick’em contests. Play now!

Bet on this game now at BetMGM Sportsbook. For more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.

JOHNNY’S RECORD W-L SP ROI
2021 MLB 55-51-2 18-18-1 +0.69
2020 MLB 80-59-1 39-21 +24.79
2021 (all sports) 158-137-3 67-60-1 +12.59
*SP: Strongest plays; ROI: Return on investment

Follow @JohnnyParlay11 on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage. This information is for entertainment purposes only. We make no representations or warranties as to the accuracy, completeness, or reliability of any content.

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