Minnesota Vikings at Indianapolis Colts odds, picks and best bets

Previewing Sunday’s Minnesota Vikings at Indianapolis Colts Week 2 betting odds and lines, with NFL betting picks, tips and best bets.

The Minnesota Vikings (0-1) and Indianapolis Colts (0-1) hook up Sunday for a Week 2 showdown at Lucas Oil Stadium at 1 p.m. ET. Below, we analyze we analyze the Vikings-Colts NFL betting odds and lines, with picks and best bets.

Vikings at Colts betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 11:47 p.m. ET.

  • Money line: Vikings +135 (bet $100, win $135) | Colts -162 (bet $162, win $100)
  • Against the spread/ATS: Vikings +3 (-110) | Colts -3 (-110)
  • Over/Under: 48.5 (O: -110, U: -110)

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Vikings at Colts game notes

  • The Colts suffered an upset at the Jacksonville Jaguars 27-20 in Week 1. The Vikings lost at home to the Green Bay Packers 43-34.
  • Minnesota has hit the Over in five of its last seven road games. Indianapolis has hit the Over in four of its last six games overall.
  • The Colts are 1-5 ATS in their last six games installed as at least a 3-point favorite.
  • Minnesota has gone Over in its last five games against AFC opponents.
  • New Colts QB Philip Rivers is 1-3 with four touchdowns and seven interceptions in his career vs. the Vikings. All three of the losses were by 17 points or more.
  • The Colts are 11-3 straight up in their last 14 home games.

Vikings at Colts key injuries

Vikings

  • CB Cameron Dantzler (ribs) questionable
  • CB Jeff Gladney (knee) questionable
  • WR Bisi Johnson (knee) questionable

Colts

  • S Julian Blackmon (knee) questionable
  • TE Jack Doyle (ankle/knee) questionable
  • S Malik Hooker (illness) questionable
  • DE Justin Houston (calf) questionable
  • WR Zach Pascal (ankle) questionable
  • WR Michael Pittman Jr. (toe) questionable
  • CB Isaiah Rodgers (ankle) questionable

Vikings at Colts: Odds, betting lines, picks and prediction

Prediction

Vikings 27, Colts 24

Money line (?)

Minnesota comes in as an +135 underdog after its defense got carved up by the Packers’ Aaron Rodgers in Week 1. However, Rivers is a glacier who has saved some of the worst games of his career for the Vikings, who get after him and force turnovers. Minnesota has playoff potential if its secondary improves. Indy doesn’t. Take MINNESOTA +135.

Against the spread (?)

AVOID. If you’re picking Minnesota to win outright, there isn’t much reason to risk $110 to win $100 by being given 3 points.

Over/Under (?)

The O/U of 48.5 seems too high for these offenses, but the defenses have to be factored in. Minnesota is in a complete overhaul of its cornerbacks and defensive line, and Indy lost to Jacksonville – which had the looks of the team that could go 0-16. If you give up 27 points to the Jaguars, the Vikings should equal or top that against the Colts defense. For a Vikings defense that was a dumpster fire that allowed a 43-burger to Green Bay in Week 1, even if they cut that in half, the combination hits higher than 48.5 points. Take the OVER.

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