San Diego Padres at San Francisco Giants odds, picks and best bets

Previewing Tuesday’s San Diego Padres at San Francisco Giants sports betting odds and lines, with MLB betting picks, tips and best bets.

The San Francisco Giants (2-2) host the San Diego Padres (3-1) in their home opener at 9:45 p.m. ET in Oracle Park. We analyze the Padres-Giants betting odds and lines, with MLB picks and best bets.

Padres at Giants: Projected starting pitchers

RHP Zach Davies vs. RHP Jeff Samardzija

Davies in 2019: 10-7 with a 3.55 ERA in 31 games started.

  • 2019 vs. Giants: 0-1 with a 2.45 ERA in two starts (3 ER, 11 IP).
  • Career vs. Giants: 0-2 with a 2.05 ERA in four starts (5 ER, 22 IP).

Samardzija in 2019: 11-12 with a 3.52 ERA in 32 games started.

  • 2019 vs. Padres: 1-1 with a 3.33 ERA in four starts (10 ER, 24 1/3 IP).
  • Career vs. Padres: 9-4 with a 3.58 ERA in 19 starts and 21 appearances (49 ER, 123 1/3 IP).

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Padres at Giants: Key injuries

Current listed MLB injuries include:

Padres

  • 1B Eric Hosmer (illness) questionable

Giants

  • 1B Brandon Belt (heel) out
  • 3B Evan Longoria (oblique) out
  • Buster Posey (personal) out
  • RP Reyes Moronta (shoulder) out
  • LF Austin Slater (hip) questionable
  • OF Billy Hamilton (undisclosed) questionable

Padres at Giants: Odds, lines, picks and betting tips

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 1:30 p.m. ET.

Prediction

Padres 5, Giants 1

Moneyline (ML)

The Padres (-143) have looked good through four games after winning the series against the Arizona Diamondbacks, three games to one. The Giants (+130) surprisingly split their opening series against the defending National League West champion Los Angeles Dodgers. San Diego was projected to win more games than San Francisco and has looked more impressive in its victories than the Giants, so I lean to them in this game.

But I do not like the Padres (-143) pricepoint and I am PASSING on this moneyline.

Run line/Against the spread (ATS)

I leaned toward San Diego (-1.5, +105) in the moneyline handicap, but that doesn’t mean I like San Francisco (+1.5, -129). There’s a lot of reasons to like the Padres here, and on the moneyline, so call me a nit, but I’m PASSING on the run line, too.

Over/Under (O/U)

Both starting pitchers have pitched well in recent outings against their respective opponents. Davies is 0-2 in his four career starts against the Giants but has a low 2.05 ERA in those games. Samardzija has a 3.38 ERA and is 1-1 in his last five starts against the Padres.

The injury report is crucial here. The absences of Posey (out for the year), Belt, and Longoria don’t bode well for a lineup that scored the third-fewest runs per game in the majors last season. Also, the Padres could be without Hosmer, who drove in seven runs in his two games.

Take the UNDER 8.5 (-110). 

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