Seattle Seahawks at Arizona Cardinals odds, picks and prediction

Previewing the Seattle Seahawks and Arizona Cardinals Week 7 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (4-2) return home after three straight road games to take on the undefeated Seattle Seahawks (5-0). The clash between the top two teams in the NFC West kicks off at State Farm Stadium at 8:20 p.m. ET Sunday of Week 7. Below, we preview the Seahawks-Cardinals Week 7 betting odds and lines and make our NFL picks and predictions.

Seahawks at Cardinals betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday 10:50 a.m. ET.

  • Money line: Seahawks -189 (bet $189, win $100) | Cardinals +160 (bet $100, win $160)
  • Against the spread/ATS: Seahawks -3.5 (-106) | Cardinals +3.5 (-115)
  • Over/Under: 55.5 (O: -110, U: -110)

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Seahawks at Cardinals game notes

  • Seahawks QB Russell Wilson leads the NFL with 19 touchdown passes.
  • Seattle has the league’s No. 1 scoring offense in the league at 33.8 points per game.
  • The Cardinals defense allows the second-fewest points per game at 18.7.
  • The Cardinals have one of the best rushing attacks in the league, as they are No. 1 in yards per carry and No. 1 in rushing touchdowns.
  • Cardinals QB Kyler Murray has 16 combined touchdowns (rushing and passing).

Seahawks at Cardinals key injuries

Seahawks

  • Jamal Adams (groin) doubtful
  • RB Carlos Hyde (shoulder) questionable
  • Mike Iupati (back) questionable

Cardinals

  • WR DeAndre Hopkins (ankle) questionable
  • CB Dre Kirkpatrick (foot) questionable
  • OL Kelvin Beachum (ankle) questionable

Seahawks at Cardinals: Odds, betting lines, picks and prediction

Prediction

Cardinals 27, Seahawks 24

Money line (?)

The Cardinals are playing defense at a high level but the Seahawks seem to be able to come back from any deficit. The Cardinals have not beaten the Seahawks at home since 2012, but Seattle allow over 470 yards of offense per game and the Cardinals have weapons to put up points. This is the game where the Seahawks can fall. Take the CARDINALS (+160).

Against the spread (?)

Seattle is 4-1 ATS this season and the Cardinals are 4-2 ATS. The Cardinals are 2-0 ATS as an underdog. Take the CARDINALS +3.5 (-115).

Over/Under (?)

Despite the talk of the Cardinals offense, it is the defense that has mattered most. All six of Arizona’s games have gone Under the total. Seattle is 3-2 O/U. While many expect a shootout, both team’s defenses will make it an entertaining game, but it will fall short of the total. Take UNDER 55.5 (-110).

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