The Seattle Seahawks (6-10) wrap up their 2021 season on the road against the Arizona Cardinals (11-5) in Week 18. Kickoff is 4:25 p.m. ET at State Farm Stadium. Below, we look at the Seahawks vs. Cardinals odds and lines, and make our best NFL picks, predictions and bets.
The Seahawks failed to qualify for the postseason for just the second time, and have a losing season for the first time, in QB Russell Wilson‘s career. It also marks the first time that they’ve lost 10 games with Pete Carroll as head coach. However, they are coming off a 51-29 home victory in Week 17 over the Detroit Lions.
The Cardinals are going to the postseason for the first time since 2015 and are in contention for the NFC West title. They snapped a three-game losing skid in Week 17 with a 25-22 win over the Dallas Cowboys.
Seahawks at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:27 a.m. ET.
- Money line: Seahawks +190 (bet $100 to win $190) | Cardinals -240 (bet $240 to win $100)
- Against the spread (ATS): Seahawks +5.5 (-112) | Cardinals -5.5 (-108)
- Over/Under (O/U): 47.5 (O: -115 | U: -105)
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Seahawks at Cardinals key injuries
Seahawks
- T Brandon Shell (shoulder, illness) out
- LB Bobby Wagner (knee) out
- LB Carlos Dunlap (ankle) questionable
- TE Will Dissly (heel) questionable
- G Gabe Jackson (knee, illness) questionable
Cardinals
- RB Chase Edmonds (ribs, toe) out
- WR Rondale Moore (ankle) out
- DL Jordan Phillips (knee) out
- CB Marco Wilson (shoulder) out
- DL Zach Allen (ankle) questionable
- RB James Conner (heel) questionable
Let’s Make This Interesting
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Seahawks at Cardinals odds, lines, predictions and picks
Prediction
Cardinals 27, Seahawks 16
Money line
The Seahawks have only lost twice to the Cardinals in State Farm Stadium since Wilson’s career started. The Cardinals are 3-4 at home this season and Seattle is 3-5 away from home. Seattle has lost two of its last three games and allowed 23 to the Cardinals in Week 9 — but it could have been 30 if Matt Prater had not missed an extra point and two field goals.
The Cardinals got their offense back on track last week and are playing for a division title. While a few players are out for the Cards, Seattle will struggle to make plays without Wagner in the middle of the defense.
Take the CARDINALS (-240).
Against the spread
The Seahawks are 8-8 ATS on the season but failed to cover the spread in their game against the Cardinals in Seattle.
The Cardinals are 10-6 ATS this season. They have the defense playing well and the offense back on track.
The Cardinals have covered the spread in all but one of their victories this season.
Take the CARDINALS -5.5 (-108).
Over/Under
Four of the Seahawks’ last five games have gone Over the projected total but only one other game all year has.
The last three games for the Cardinals stayed Under the projected total and their game in Seattle went Under.
Take UNDER 47.5 (-105).
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