Rams are biggest underdogs of Sean McVay era vs. 49ers in Week 16

The Rams opened as 6.5-point underdogs to the 49ers in Week 16.

The Rams’ season didn’t end on Sunday in Dallas with their 44-21 loss, but their postseason chances did take a huge hit. Sitting two games behind the Vikings for the sixth seed in the NFC, the Rams need to win their next two and have Minnesota lose out.

That doesn’t look like an easy proposition, especially with the Rams visiting the 49ers next. It’s a prime-time Saturday night matchup between two teams that are coming off disappointing losses, with each still in the playoff race.

The 49ers were stunned at home by the Falcons on Sunday and will look to bounce back with a win over the Rams. They’re unsurprisingly favored in the game, as they have been in most of their contests this year.

According to BetMGM, the Rams are 6.5-point underdogs to the 49ers in Week 16. The over/under is 46.5 points. Incredibly, that’s the most points they’ve been underdogs by since Sean McVay took over as head coach in 2017.

Previously, their Week 17 game against the 49ers two years ago when they rested their starters was the largest spread against them (6.0 points). The Rams have been underdogs just twice this season: at home against Baltimore and on the road against Seattle.

They have the talent to cover the 6.5-point spread, especially after the 49ers just lost to the Falcons at home, but the last time these teams met, San Francisco was dominant. The 49ers rolled to a 20-7 win, limiting the Rams to just 157 total yards and 10 first downs.

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NFL announces Rams-49ers will be on Saturday night in Week 16

The NFL awarded Rams-49ers a prime-time slot in Week 16, with kickoff at 8:15 p.m. ET on Saturday night.

The Los Angeles Rams are quickly falling out of playoff contention with each mounting loss, seeing their postseason odds drop to 16.5 percent after Week 10’s results. Yet, the NFL still wants them in prime time late in the season.

The league announced on Tuesday that the Rams-49ers matchup in Week 16 will be held on Saturday night. There were three time slots available on Saturday in Week 16 with five games to choose from, and the NFL decided to give this NFC West showdown was given a marquee spot.

Bills-Patriots will be at 4:30 p.m. ET, with Texans-Buccaneers taking place at 1 p.m. ET that Saturday. The other two games – Raiders-Chargers and Lions-Broncos – will be on Sunday.

This means four of the Rams’ final seven games will be in prime time, with two in a row coming up against the Bears (SNF) and Ravens (MNF) the following week.

When Week 16 rolls around, the Rams hope to be in playoff contention. If not, they’ll try to play spoiler against the 49ers and drop them down in the postseason seeding.