The Los Angeles Rams (8-6) need a miracle in order to make the playoffs, and facing the San Francisco 49ers (11-3) won’t help their cause. This NFC West clash takes place Saturday night at Levi’s Stadium, kicking off at 8:15 p.m. ET. We analyze the Rams-49ers odds and lines, with NFL betting picks and tips for the Week 16 matchup.
Rams at 49ers: Week 16 preview, betting trends and notes
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- The 49ers beat the Rams 20-7 in Week 6. The Rams were held to 48 net passing yards and 157 total yards, picking up a season-low 10 first downs.
- The Rams are 5-5 straight up against the 49ers in their last 10 head-to-head meetings, but 4-6 against the spread in those games. They’ve outscored the 49ers 22.5-22.0 on average over their last 10.
- Los Angeles is only 2-6 ATS in its last eight meetings with the 49ers.
- The 49ers are just 1-2 SU in their last three games after starting the season 10-1.
- The total has gone Under in seven of the Rams’ last nine games, but it has gone Over in six of the 49ers’ last eight games.
- The Under is 5-1 in the 49ers’ last six home games against the Rams.
Rams at 49ers: Key injuries
Rams CB Troy Hill broke his thumb Sunday and underwent surgery, but he could play. PK Greg Zuerlein (quad) is expected to play but it’s not certain.
49ers CB Richard Sherman and DE Dee Ford both have hamstring injuries and are questionable. CB K’Waun Williams (concussion) is on track to play.
Rams at 49ers: Odds, betting lines and prediction
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 12:15 p.m. ET.
Prediction
49ers 24, Rams 20
Moneyline (?)
The Rams looked good for two straight weeks before getting blown out by the Dallas Cowboys. The 49ers are still the better team and have been more consistent this season, and based on their last performance against the Rams, this is a game they should win.
Bet the 49ERS (-278) to win straight-up Saturday night at home.
Against the Spread (?)
The 49ers come into this one as 6.5-point favorites over the Rams, who were just beaten by 23 points on the road. San Francisco is 7-3 ATS in its last 10 games but covering the spread Saturday will be tough.
The Rams typically bounce back well from losses and they will this weekend. Bet the RAMS (+6.5, -115) to cover the spread and keep things close.
Over/Under (?)
The projected total is 45.5 points. That’s a tricky number because while the Rams and 49ers can both light up a scoreboard, their defenses are both very good.
Take the UNDER 45.5 (-115) and expect both defenses to play well, limiting the opposing offenses throughout the night.
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