Pittsburgh at Notre Dame odds, picks and predictions

Analyzing Saturday’s Pittsburgh at Notre Dame odds and lines, with college football expert picks, predictions and best bets.

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The Pittsburgh Panthers (2-5) and Notre Dame Fighting Irish (6-2) meet Saturday at Notre Dame Stadium. Kickoff is scheduled for 3:30 p.m. ET (NBC). Below, we analyze BetMGM Sportsbook’s lines around the Pittsburgh vs. Notre Dame odds, and make our expert college football picks and predictions.

The Panthers are coming off a 21-17 loss at Wake Forest last Saturday. However, Pitt showed it can still be dangerous, and explosive, topping Louisville by a 38-21 count at Acrisure Stadium as a 7-point underdog. It’s the same Cardinals team which topped the Fighting Irish 33-20 the week before.

Notre Dame rebounded from that setback at Louisville on Oct. 7 with a 48-20 humbling of USC in the shadows of Touchdown Jesus. The Irish have a lone setback on the home ledger, falling to Ohio State on the final play of regulation on Sept. 23, although the Irish covered that game. In fact, Notre Dame is 3-1 against the spread (ATS) at home this season, with the lone non-cover a 41-17 win over Central Michigan on Sept. 16.

Notre Dame is No. 14 in the US LBM Coaches Poll powered by USA TODAY Sports.

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Pittsburgh at Notre Dame odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 8:27 p.m. ET.

  • Moneyline (ML): Pittsburgh +800 (bet $100 to win $800) | Notre Dame -1400 (bet $1,400 to win $100)
  • Against the spread (ATS): Pittsburgh +20.5 (-110) | Notre Dame -20.5 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Pittsburgh at Notre Dame picks and predictions

Prediction

Notre Dame 31, Pittsburgh 13

Moneyline

Notre Dame (-1400) is way too expensive to bet straight up or as part of a multi-team parlay.

AVOID, and look to the spread instead.

Against the spread

PITTSBURGH +20.5 (-110) is worth a look catching nearly 3 touchdowns, although be careful. This Panthers offense has been moribund most of the season, going for just 320.4 total yards per game, and 111.1 rushing yards per contest. However, it did top Louisville, a team which beat Notre Dame -20.5 (-110).

The Panthers have a pretty solid defense, ranking 27th in the nation with just 195.3 opponent passing yards per game, so they should be able to hold QB Sam Hartman down somewhat, keeping the Irish within hailing distance.

Over/Under

UNDER 45.5 (-110) is the lean. Pitt has scored 21 or fewer points in 4 of the past 6 games, including all 3 road games this season. The Panthers are averaging a paltry 14.7 PPG in those 3 away contests.

The Irish have cashed the Under in 3 of the past 4 games, and the lone Over is against USC’s atrocious defense. The Panthers might not be great offensively, but they can be a pesky defense, especially against the pass.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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