Patriots Bills betting odds lines money line against the spread Over Under

The New England Patriots (10-7) and Buffalo Bills (11-6) meet Saturday for an AFC Wild Card matchup. Kickoff from Highmark Stadium is set for 8:15 p.m. ET. Below, we look at the Patriots vs. Bills odds and lines; check back for our NFL picks and predictions.

The Patriots stumble into the playoffs with just one win over their last four games, including a 33-24 road loss to the Miami Dolphins to close out the season.

New England fell behind 14-0 just nine minutes into the first quarter when Miami returned a QB Mac Jones interception for a touchdown. Jones finished with 261 passing yards and 1 TD against 1 INT.

New England is returning to the playoffs after failing to reach them in 2020, the first time it had fallen short in 11 years.

The Bills rattled off four consecutive victories to finish their season after dropping two games in early December.

Buffalo recorded a 27-10 home victory that wrapped up with 2 fourth-quarter touchdowns from RB Devin Singletary (one rushing, one receiving) who finished the game with 88 yards on 19 carries and 2 receptions for 24 yards.

Buffalo held New York to just 53 total yards (48 rushing and 5 net passing yards), held the Jets to just 1-for-14 on third-down conversions and dominated time of possession 37:00 – 23:00.

Buffalo’s victory clinched it the AFC East title for the second consecutive year.

Also see: All Wild Card odds and lines

Patriots at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:40 p.m. ET.

Money line: Patriots +170 (bet $100 to win $170) | Bills -210 (bet $210 to win $100)
Against the spread (ATS): Patriots +3.5, -103 (bet $103 to win $100) | Bills -3.5, -117 (bet $117 to win $100)
Over/Under (O/U): 43.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

Also see: Betting 101

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

2021 betting stats:

ML: Patriots 10-7 | Bills 11-6
ATS: Patriots 10-7 | Bills 9-6-2
O/U: Patriots 9-8 | Bills 8-9

Patriots at Bills head-to-head

The Patriots lead the all-time series with the Bills 77-46-1, a record that includes a 1-0 mark in the postseason (1963 Divisional Round).

The Bills have won three of four meetings (2-2 ATS) with the Pats since QB Tom Brady left New England following the 2019 season, and the teams split this season’s meetings. New England picked up a 14-10 road victory in Week 13 and Buffalo captured a 33-21 road victory in Week 16.

The Patriots hold a small 5-4-1 ATS margin over the last 10 games between the two sides, while the Over has connected in four of those affairs.

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW. Please gamble responsibly.

Follow Andrew Reid on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]

For at least one day, the New England Patriots are the top seed in the AFC. If they can upset the Buffalo Bills on the road on Monday night, they’ll extend their rule to at least two weeks.

This Week 13 showdown isn’t just a battle between divisional rivals; it’s a game that will have lasting implications on the conference’s playoff race. A 9-4 Patriots team would take a 1.5-game lead over the Bills into its bye week before a challenging four-game stretch to close the season. A Buffalo win would push Josh Allen’s team to 8-4 and into a four-way tiebreaker situation for the AFC’s No. 1 spot.

More importantly, a Bills victory would prove their November struggles were an aberration, not a warning. Buffalo struggled through a 2-3 stretch that threw debris on their path to a second-straight division title and nearly sent the team spiraling (losing to the Jaguars will do that). Handling the Saints on Thanksgiving was a step in the right direction, but knocking off the Pats in front of a raucous, cinnamon schnapps-smelling home crowd would serve as proof the Bills are, in fact, one of the truest contenders.

Can Buffalo make that statement in front of a national audience? Will New England keep its hot streak rolling and send a disappointed crowd back to a parking lot littered with broken folding tables?

Let’s talk about it. All odds via Tipico.