Oregon at Michigan odds, picks and predictions

Analyzing Saturday’s Oregon at Michigan odds and lines, with college football expert picks, predictions and best bets.

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The No. 1 Oregon Ducks (8-0, 5-0 Big Ten) and the Michigan Wolverines (5-3, 3-2) meet Saturday at Michigan Stadium. Kickoff is scheduled for 3:30 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s college football odds around the Oregon vs. Michigan odds, and make our expert college football picks and predictions.

The Ducks kept their perfect season intact with a commanding 38-9 win over No. 24 Illinois. Oregon covered the 23-point spread at home while the game stayed under the 53.5-point total. Heisman contender QB Dillon Gabriel threw for 291 yards, 3 TDS and a 1 INT. His go-to receiver, Tez Johnson, had 6 catches for 102 yards and a TD.

The Wolverines broke their 2-game skid with a 24-17 victory over the rival Michigan State Spartans, covering the 3-point spread at home and hitting the over on the 38.5-point total. Davis Warren stepped up as starting QB, throwing for 123 yards and a TD, while QB Alex Orji rushed for 64 yards and a score. TE Colston Loveland caught 2 D passes, including 1 from RB Donovan Edwards.

– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Oregon vs. Michigan odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 6:13 a.m. ET.

  • Moneyline (ML): Oregon -700 (bet $700 to win $100) | Michigan +500 (bet $100 to win $500)
  • Against the spread (ATS): Oregon -14.5 (-115) | Michigan +14.5 (-105)
  • Over/Under (O/U): 45.5 (O: -115 | U: -105)

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Oregon vs. Michigan picks and predictions

Prediction

Oregon 38, Michigan 17

Moneyline

PASS.

Oregon (-700) appears unstoppable and Michigan (+500) is next in their path. Expect this game to get ugly fast—just like when the Texas Longhorns steamrolled the Wolverines. I’m betting on the Ducks to cover.

Against the spread

BET OREGON -14.5 (-115).

The Ducks clearly boast superior talent and can capitalize on their offensive explosiveness. Their 4-4 ATS record is misleading; They could realistically be 6-2 ATS if they hadn’t eased off in the second halves of games against UCLA and Michigan State, allowing those teams to score late. Given the importance of this matchup and the chance for Oregon to make a statement against a prestigious opponent, a decisive victory seems likely.

Oregon has an impressive history, winning 30 of its last 31 games against non-AP-ranked teams and covering the spread in 6 of their last 7 November games as favorites. Meanwhile, Michigan has struggled to cover, failing in 6 of their last 8 games and 3 of their last 4 home games in November. With this in mind, expect the Ducks to continue their strong performance and cover the spread convincingly.

Over/Under

BET OVER 45.5 (-115).

The Ducks, under the leadership of Gabriel, have established themselves as a formidable offensive powerhouse this season. Averaging 35 points per game, Oregon ranks 25th nationally as they head into Week 10. Their games have typically seen an average of 50.6 total points, with an average O/U line of 55.3. However, this week’s line is set at 45.5 points, the lowest they’ve faced all season.

Michigan’s defense, while often touted as a strength, ranks 32nd nationally in scoring defense, allowing 21.5 points per game. Critics may cite Michigan’s defense as a reason for potential Unders, but the Wolverines have faced a relatively easy schedule, with opponents averaging a national ranking of 71.2 in scoring offense. Notably, they’ve allowed at least 21 points to every Power 5 team they faced, except last week against a struggling Michigan State team.

Given both teams’ offensive capabilities and the potential for defensive lapses—especially with Oregon adjusting to the absence of key players—this matchup is primed for significant scoring. The Ducks’ quick-strike ability, coupled with Michigan’s push for home-field dominance, suggests a high-scoring affair is on the horizon. Thus, betting on the Over seems like a compelling option for this highly anticipated Big Ten showdown.

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