NFL Week 5 odds and lines: Money line, spread and Over/Under for all 16 games

Looking at the NFL odds and lines for the Week 5 slate, with money lines, spreads and Over/Unders for all 16 games.

As we await the result of Monday Night Football’s Las Vegas Raiders (3-0) at Los Angeles Chargers (2-1) matchup, the Arizona Cardinals (4-0) are the only other undefeated team through four weeks. Only two teams – the Jacksonville Jaguars and Detroit Lions – are winless at 0-4. Below, we look at the Week 5 NFL odds and lines; check back for our NFL picks and predictions.

The Cards improved to 4-0 and dropped the NFC West rival Los Angeles Rams to 3-1 with a dominant 37-20 victory on the road at SoFi Stadium in Week 4. They’ll return home for another divisional matchup against the San Francisco 49ers in Week 5. The Rams and Seattle Seahawks will start the week with Thursday Night Football.

Odds provided by Tipico Sportsbook and last updated Monday, Oct. 4.

PLAY: Our new free daily Pick’em Challenge and win! Play now!