SportsbookWire’s NFL Week 2 picks: ML, ATS and O/U predictions for all games

The SportsbookWire staff makes their NFL Week 2 picks and predictions for moneylines, spreads and totals.

Week 2 kicks off with an AFC East showdown in South Florida Thursday night as the Miami Dolphins host the Buffalo Bills in a meeting of 1-0 rivals.

There are 5 more matchups involving 1-0 teams facing off Sunday.

They include the Dallas Cowboys hosting the New Orleans Saints, the Detroit Lions welcoming the Tampa Bay Buccaneers, the San Francisco 49ers at the Minnesota Vikings, the Seattle Seahawks at the New England Patriots and the Chicago Bears at the Houston Texans in the prime-time game.

The week concludes with the Atlanta Falcons (0-1) at the Philadelphia Eagles (1-0) on Monday Night Football at 8:20 p.m. ET (ABC / ESPN).

Before getting to SportsbookWire.com staff’s Week 2 NFL picks, here’s a quick rundown of Week 1.

Favorites went 13-3 straight up and 9-7 against the spread, while the Over was 9-7.

NFL Week 2 staff picks

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds and check out more NFL expert picks and predictions from SportsbookWire.com.

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SportsbookWire’s NFL Week 2 picks: ML, ATS and O/U predictions for all games

The SportsbookWire staff makes their NFL Week 2 picks and predictions for moneylines, spreads and totals.

Now that everyone has got their feet wet with the opening week of the NFL regular season, it’s time to get serious.

All 3 of the quarterbacks selected in the top 10 of this summer’s NFL Draft will be seeking their 1st career wins in Week 2 after coming up short in their debuts.

First-overall selection QB Bryce Young and the Carolina Panthers, who lost 24-10 to the Atlanta Falcons, host the New Orleans Saints (1-0) Monday.

No. 2 pick C.J. Stroud of the Houston Texans and No. 4 pick Anthony Richardson of the Indianapolis Colts both lost their openers. However, one of them should prevail in Week 2 as Indy visits Houston Sunday.

The week opened with the Philadelphia Eagles (2-0) claiming a 34-28 home win vs. the Minnesota Vikings (0-2) — pushing as 6-point favorites — on Thursday Night Football.

The New England Patriots (0-1) welcome the Miami Dolphins (1-0) for an AFC East tilt on Sunday Night Football.

Monday features a doubleheader with the Saints at the Panthers in an NFC South matchup and the Cleveland Browns (1-0) at the Pittsburgh Steelers (0-1) in an AFC North showdown.

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NFL Week 2 staff picks

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list and check out more NFL expert picks and predictions from SportsbookWire.com.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

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