The first Sunday of the 2021 NFL season is here. SportsbookWire.com runs through the opening slate, with NFL picks, predictions and best bets against the money line, spread and Over/Under. Check out our staff picks and predictions before locking in your Week 1 bets.
The Dallas Cowboys and Tampa Buccaneers got the season underway Thursday night. The Buccaneers won 31-29 but the Cowboys covered as 8.5-point underdogs and the game sailed Over the projected total of 51.5 points.
Also see: NFL team win totals, playoff lines and Super Bowl odds
Odds provided by Tipico Sportsbook.
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