The Kansas City Chiefs (1-0) are seeking a 2-0 start after dominating the Houston Texans in the season opener, and they’ll take on their division rival Los Angeles Chargers (1-0) who also won in Week 1. Kickoff from SoFi Stadium in Inglewood will be at 4:25 p.m. ET.
Chiefs at Chargers betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday, 1:50 p.m. ET.
- Money line: Chiefs -385 (bet $385, win $100) | Chargers +300 (Bet $100, win $300)
- Against the Spread/ATS: Chiefs -8.5 (-110) | Chargers +8.5 (-110)
- Over/Under: 47.5 (O: -110, U: -110)
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Chiefs at Chargers game notes
- The Chiefs are 7-0 ATS in their last seven road games against the Chargers.
- The Chiefs are 10-0 ATS in their last 10 games dating back to last season.
- The Chargers have lost six straight games against the AFC West, while the Chiefs have won seven straight.
- The Chiefs were fourth in scoring and rushing yards after Week 1, but QB Patrick Mahomes only had the 24th-most passing yards in Week 1.
- The Chargers allowed just 13 points to the Bengals in Week 1 and gave up the fifth-fewest passing yards in the opener.
Chiefs at Chargers key injuries
Chiefs
- CB Charvarius Ward (hand) questionable/DNP Thursday
- DE Alex Okafor (hamstring) questionable/DNP Thursday
- CB Bashaud Breeland (suspension) out
Chargers
- DE Joey Bosa (triceps) probable/limited Thursday practice
- RB Justin Jackson (quad) questionable/DNP Thursday
- S Derwin James (knee) IR
- C Mike Pouncey (hip) out for the season
Chiefs at Chargers: Odds, betting lines, picks and prediction
Prediction
Chiefs 30, Chargers 20
Money line (?)
The money line in this game is so lopsided that it’s hard to find a good value. The Chiefs are -385, making them the biggest favorites of any team this week. As likely as they are to win and as dominant as they looked in Week 1, I just don’t feel great about the -385 line and the risk-reward of it.
I’m going to PASS on the money line and look toward the spread.
Against the Spread (?)
The Chiefs are giving up 8.5 points to the Chargers but as big of a spread as that is, it’s easy to see a scenario in which they win by double digits. The Chargers are beaten up injury-wise and lack explosiveness on offense, while the Chiefs defense is no slouch, either.
Take the CHIEFS -8.5 (-110) to cover the spread and win by 10 points.
Over/Under (?)
The total went over in the Chiefs’ season opener, but under in the Chargers’ Week 1 game. It’s gone over in four of the Chiefs’ last five games dating back to last year and in four of the last six for the Chargers, and it’s a good bet to go over again this weekend.
Unless the Chargers find a way to disrupt this Chiefs offense, Kansas City will be good for 30 points on its own. The Chargers probably just need to score a couple of touchdowns to put the total over.
Bet the OVER 47.5 (-110) on Sunday afternoon.
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