New England Patriots vs. Buffalo Bills odds lines money line against the spread Over Under

First look: New England Patriots at Buffalo Bills odds and lines

Looking at Sunday’s New England Patriots at Buffalo Bills Week 16 NFL odds, lines and trends. Here’s what you need to know.

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The New England Patriots (3-11) will visit the Buffalo Bills (11-3) Sunday for a Week 16 AFC East showdown. Opening kickoff at Highmark Stadium is scheduled for 1 p.m. ET (CBS). Below, we look at Patriots vs. Bills odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Patriots lost 30-17 as 6-point underdogs at the Arizona Cardinals Sunday in Week 15 with the Over (46) squeaking in. New England trailed throughout, getting outscored 10-0 in the opening quarter. The Pats now head to Western New York with a 4-game losing streak in tow.

In a marquee Week 15 matchup, the Bills defeated the Detroit Lions 48-42 Sunday. Buffalo looked impressive as 2.5-point road underdogs with the Over (55.5) cashing. Buffalo QB Josh Allen threw for 362 yards with 2 TDs, while also running for 68 yards with 2 more scores. It was the second straight game with both sides scoring 40-plus — the Bills lost at the LA Rams 44-42 in Week 14.

Sunday’s contest will mark the first of 2 between the Pats and Bills in a 3-week span. They close out their regular-season schedules with a Week 18 game at New England.

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Patriots at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 3:49 a.m. ET.

Moneyline: Patriots +600 (bet $100 to win $600) | Bills -900 (bet $900 to win $100)
Against the spread (ATS): Patriots +14 (-110) | Bills -14 (-110)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

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2024 betting stats

ML: Patriots 3-11 | Bills 11-3
ATS: Patriots 5-8-1 | Bills 9-5
O/U: Patriots 9-5 | Bills 9-4-1

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Patriots vs. Bills head-to-head

New England leads the all-time series 78-50-1. The series began in 1960 and includes a 1-1 split in playoff games.

Buffalo took the most recent meeting 27-21 in Week 17 of last season, but didn’t cover as a 14.5-point home favorite. The Bills have won 5 of the last 6 games with the loss a 29-25 stunner as 8.5-point road favorites in Week 7 last year.

The Patriots are 38-26-1 across 65 series meetings held in Buffalo.

As mentioned, New England covered the spread in both games last season, following a Buffalo 4-0 ATS run. The last 10 meetings have netted a 5-5 split ATS.

The Over has cashed in 3 straight New England-Buffalo games and is 7-2-1 across the last 10 meetings.

The last 3 matchups at Highmark Stadium have resulted in the Bills covering twice and the Over hitting each time.

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First look: New England Patriots at Buffalo Bills odds and lines

Looking at Saturday’s New England Patriots at Buffalo Bills Wild Card NFL odds, lines and trends. Here’s what you need to know.

The New England Patriots (10-7) and Buffalo Bills (11-6) meet Saturday for an AFC Wild Card matchup. Kickoff from Highmark Stadium is set for 8:15 p.m. ET. Below, we look at the Patriots vs. Bills odds and lines; check back for our NFL picks and predictions.

The Patriots stumble into the playoffs with just one win over their last four games, including a 33-24 road loss to the Miami Dolphins to close out the season.

New England fell behind 14-0 just nine minutes into the first quarter when Miami returned a QB Mac Jones interception for a touchdown. Jones finished with 261 passing yards and 1 TD against 1 INT.

New England is returning to the playoffs after failing to reach them in 2020, the first time it had fallen short in 11 years.

The Bills rattled off four consecutive victories to finish their season after dropping two games in early December.

Buffalo recorded a 27-10 home victory that wrapped up with 2 fourth-quarter touchdowns from RB Devin Singletary (one rushing, one receiving) who finished the game with 88 yards on 19 carries and 2 receptions for 24 yards.

Buffalo held New York to just 53 total yards (48 rushing and 5 net passing yards), held the Jets to just 1-for-14 on third-down conversions and dominated time of possession 37:00 – 23:00.

Buffalo’s victory clinched it the AFC East title for the second consecutive year.

Also see: All Wild Card odds and lines

Patriots at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 2:40 p.m. ET.

Money line: Patriots +170 (bet $100 to win $170) | Bills -210 (bet $210 to win $100)
Against the spread (ATS): Patriots +3.5, -103 (bet $103 to win $100) | Bills -3.5, -117 (bet $117 to win $100)
Over/Under (O/U): 43.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: Patriots 10-7 | Bills 11-6
ATS: Patriots 10-7 | Bills 9-6-2
O/U: Patriots 9-8 | Bills 8-9

Patriots at Bills head-to-head

The Patriots lead the all-time series with the Bills 77-46-1, a record that includes a 1-0 mark in the postseason (1963 Divisional Round).

The Bills have won three of four meetings (2-2 ATS) with the Pats since QB Tom Brady left New England following the 2019 season, and the teams split this season’s meetings. New England picked up a 14-10 road victory in Week 13 and Buffalo captured a 33-21 road victory in Week 16.

The Patriots hold a small 5-4-1 ATS margin over the last 10 games between the two sides, while the Over has connected in four of those affairs.

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Monday Night Football picks and prop bets: The Patriots, the Bills, and the battle for the AFC

The fate of the AFC East — and maybe the AFC in general — rests in Orchard Park.

For at least one day, the New England Patriots are the top seed in the AFC. If they can upset the Buffalo Bills on the road on Monday night, they’ll extend their rule to at least two weeks.

This Week 13 showdown isn’t just a battle between divisional rivals; it’s a game that will have lasting implications on the conference’s playoff race. A 9-4 Patriots team would take a 1.5-game lead over the Bills into its bye week before a challenging four-game stretch to close the season. A Buffalo win would push Josh Allen’s team to 8-4 and into a four-way tiebreaker situation for the AFC’s No. 1 spot.

More importantly, a Bills victory would prove their November struggles were an aberration, not a warning. Buffalo struggled through a 2-3 stretch that threw debris on their path to a second-straight division title and nearly sent the team spiraling (losing to the Jaguars will do that). Handling the Saints on Thanksgiving was a step in the right direction, but knocking off the Pats in front of a raucous, cinnamon schnapps-smelling home crowd would serve as proof the Bills are, in fact, one of the truest contenders.

Can Buffalo make that statement in front of a national audience? Will New England keep its hot streak rolling and send a disappointed crowd back to a parking lot littered with broken folding tables?

Let’s talk about it. All odds via Tipico.

First look: New England Patriots at Buffalo Bills odds and lines

Looking at Monday’s New England Patriots at Buffalo Bills Week 13 NFL odds, lines and trends. Here’s what you need to know.

The New England Patriots (8-4) and Buffalo Bills (7-4) meet in the Week 13 Monday Night Football game at Highmark Stadium. Kickoff is slated for 8:15 p.m. ET. Below, we look at the Patriots vs. Bills odds and lines; check back for our NFL picks and predictions.

New England clobbered the Tennessee Titans 36-13 for a sixth win in a row. QB Mac Jones threw for a career-high 310 yards in the triumph at home. The Pats now hit the road where they are 5-0 this season.

The Bills throttled the New Orleans Saints 31-6 Thanksgiving night. Buffalo outgained New Orleans 361 yards to 190, and QB Josh Allen completed 23 of 28 pass attempts while tossing 4 touchdowns. The defensive performance was the fourth time the Bills held an opponent under 10 points this season.

Also see: All Week 13 odds and lines

Patriots at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:20 p.m. ET.

Money line: Patriots +130 (bet $100 to win $130) | Bills -160 (bet $160 to win $100)
Against the spread (ATS): Patriots +3.5, -130 (bet $130 to win $100) | Bills -3.5, +105 (bet $105 to win $100)
Over/Under (O/U): 43.5, O: -115 (bet $115 to win $100) | U: -105 (bet $105 to win $100)

Also see: Betting 101

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2021 betting stats:

ML: Patriots 8-4 | Bills 7-4
ATS: Patriots 8-4 | Bills 6-4-1
O/U: Patriots 6-6 | Bills 5-6

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Patriots at Bills head-to-head

Buffalo took last season’s series 2-0, winning by 3 and 29 points in the twin wins. Those victories came on the heels of a seven-game New England win streak in a series that dates back to 1960. The Patriots lead that all-time series 76-45-1.

Against the spread, the Bills have gone 3-1-1 in their last five games against the Pats. The Under is 4-2 across the last six meetings.

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