First look: Nebraska at Oklahoma odds and lines

Previewing the Nebraska at Oklahoma Week 3 matchup, with college football odds, trends and head-to-head records.

It’s a rivalry renewed Saturday when the Nebraska Cornhuskers (2-1) face the No.3 Oklahoma Sooners (2-0) at Gaylord Family Oklahoma Memorial Stadium. Kickoff is set for noon p.m. ET. Below, we look at the Nebraska at Oklahoma odds and lines; check back for our college football picks and predictions.

Rankings according to the AFCA Coaches Poll powered by USA TODAY Sports.

Nebraska recovered from its opening-week loss at Illinois with a pair of blowout covers against lighter competition (52-7 vs. Fordham; 28-3 vs. Buffalo). The Cornhuskers have been efficient and balanced in those last two games with an average of 275 yards rushing and 300 yards passing, but the degree of difficulty gets much tougher this week against the Sooners.

Oklahoma has looked prolific offensively through two games behind Heisman Trophy contender QB Spencer Rattler. There were some defensive holes in its Week 1 win against Tulane as it gave up 35 points and 396 yards to the Green Wave, but the Sooners blew out Western Carolina 76-0 last week in a glorified scrimmage, outgaining the Catamounts 624-178 in total yards.

Nebraska at Oklahoma odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 12:40 p.m. ET.

  • Money line: Nebraska +750 (bet $100 to win $750) | Oklahoma -1400 (bet $1,400 to win $100)
  • Against the spread (ATS): Nebraska +22.5, -112 (bet $112 to win $100) | Oklahoma -22.5, -108 (bet $108 to win $100)
  • Over/Under (O/U): 61.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

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2021 betting stats:

  • ML: Nebraska 2-1 | Oklahoma 2-0
  • ATS: Nebraska 2-1 | Oklahoma 1-1
  • O/U: Nebraska 1-1-1 | Oklahoma 2-0

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Nebraska at Oklahoma head-to-head

These teams last played in the 2010 Big 12 Championship Game, but previously faced each other nearly every year as members of the Big Eight and Big 12 conferences. Oklahoma holds the all-time series lead 45-38-3 and has won five of the last six games dating back to 2004.

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