Prediction and betting odds for MSU vs. Indiana in Week 10

Analyzing Saturday’s Michigan State-Indiana game with odds and lines, predictions and best bets

Michigan State football returns home on Saturday and will again be listed as an underdog.

The Spartans will look to bounce back from a tough rivalry loss against Michigan this past weekend in a home matchup against undefeated Indiana. The Hoosiers have shocked the college football world with a perfect 8-0 start to the season.

Michigan State comes into this matchup with a 4-4 overall record and 2-3 mark in conference play. Michigan State is 3-1 in home games this year, with the lone loss coming against Ohio State earlier this year.

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Michigan State vs. Indiana game odds:

All College Football Odds via BetMGM:

  • Point spread: Indiana -6.5
  • Money line: Indiana -245 / Michigan State +198
  • Over-under: 50.5

Michigan State vs. Indiana prediction, pick

Indiana has been a wagon this year. There’s no other way to put it. So my early read for this matchup is a Hoosiers victory in a close game. As the week goes on, my thoughts may change on this one, especially if we get more info on whether or not Indiana starting quarterback Kurtis Rourke is able to play this week.

Prediction: Michigan State 23, Indiana 31

Michigan State vs. Indiana channel, start time, streaming:

The Michigan State vs. Indiana game starts at 3:30 p.m. ET and can be seen via streaming on Peacock.

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Get more betting analysis and predictions at Sportsbook Wire.